Description
Springer A Case Approach to Perioperative Drug-Drug Interactions 1st Editon 2015 Softbound by Catherine Marcucci, Michael P. Hutchens, Erica D. Wittwer, Toby N. Weingarten, Juraj Sprung, Wayne T. Nicholson, Kirk Lalwani, David G. Metro, Randal O. Dull, Christopher E. Swide, F. Jacob Seagull, J
The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, as well as trainees in both specialties; intensive care staff, including physicians, physician’s assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics. Part I. Introduction to Drug-Drug Interactions.- 1. Let’s Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions.- 2. Pharmacodynamic Interactions: Core Concepts.- 3. Pharmacokinetic Interactions: Core Concepts.- 4. A Brief Treatise On The Area Under The Curve.- Part II. Introduction to Drug-Drug Interactions: Brief Review of CYP450 Enzymes, UGTs, and Transporters.- 5. CYP2D6: Where It All Began.- 6. CYP2E1: The Anesthesia Enzyme.- 7. CYP3A4: The Workhorse.- 8. CYP1A2: The Switch-hitter.- 9. CYP2B: 2B or Not 2B?- 10. CYP2C9: The Support Crew I.- 11. CYP2C19: The Support Crew II.- 12. UGTs: Conjugating Cousins.- 13. The Cytochrome P450 System In Disease States—A Brief Review.- PART III. Drug-Drug Interactions: Paradigms and Core Concepts.- 14. P-glycoprotein and OATP Transporters.- 15. The “Fatal” Forty.- 16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions.- 17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma.- 18. Pharmacogenomics.- 19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important.- 20. The Lawyers Can Read, Too: Case Presentations from the Courtroom.- Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents.- 21. Introduction.- 22. That Sums It Up.- 23. 1+1+1+1=?.- 24. A Delayed Surgeon Is A “Dismayed” Surgeon?.- 25. Relax, It’s Only Gentamicin.- 26. Jaundice After Surgery.- 27. Everybody Clear?.- 28. The Hemodynamic Hole.- 29. Alpha-2 To The Rescue But Beware Bradycardia.- 30. Hot Stuff!.- Part V. Drug-Drug Interactions Involving Intravenous Anesthetic Agents.- 31. Introduction.- 32. How to Successfully Occlude an Intravenous Line.- 33. A Curious Cause of Seizures.- 34. Magnesium Mama And The Mad Dad.- 35. Dexy’s Midnight Spinal.- Part VI. Drug-Drug Interactions Involving Local Anesthetics.- 36. Introduction.- 37. Comfortably Numb.- 38. Naturally Occurring And Nasty.- 39. LOL-LOL: Little Old Lady—Lots of Lido.- 40. The Spinal Countdown.- 41. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun I.- 42. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun II.- 43. A Perfect Storm?.- 44. Shake Rattle and Roll.- 45. Hello, We Have A Patient With Acute Delirium and We Need An Urgent Psych Consult.- 46. Fatal Pain Relief.- 47. Lipid Lifesaver.- Part VII. Drug-Drug Interactions Involving Opioids.- 48. Introduction.- 49. No ‘Subs’titute for Sobriety.- 50. A Needle And The Damage Done.- 51. Dad’s Not Having Much Pain.- 52. Royal Flush.- 53. The Worry That’s Always With Us: Afternoon Nap.- 54. The Bawling Baby.- 55. Sleeping Beauty.- 56. Codeine Can’t Do It.- 57. A Shuddering Interaction.- 58. Double Indemnity.- 59. Breaking the Codeine .- 60. The Ultimate Ultram Primer I: My Mood Is Better, But Boy Do I Hurt!.- 61. The Ultimate Ultram Primer II: I “Haight” Narcotics But I Hate Seizures Worse.- 62. The Ultimate Ultram Primer III: Tremor-dol Trigger in Serotonin Syndrome.- 63. Too Much of A Good Thing.- Part VIII. Drug-Drug Interactions Involving Non-opioid Pain Medications.- 64. Introduction.- 65. Pining For Pete In The Pain Clinic.- 66. You Do Not Look Well Today, Mon Ami.- 67. My Headache is Gone, But My Leg Now Hurts.- 68. Special ‘K’ase.- 69. Not Manic About NSAIDs.- 70. Keep It Capped!.- 71. The ACE Is Not Always High.- 72. When The Smoke Clears, Relaxation Disappears.- 73. Befuddled by Aspirin.- 74. You Can’t Trick Us!.- Part IX. Drug-Drug Interactions Involving Benzodiazepines and Other Sedatives.- 75. Introduction.- 76. The Worry That’s Always With Us: Now I’m Depressed.- 77. The Worry That’s Always With Us: Tragic But Not Rare.- 78. Lack of Sedation.- 79. A Cold Isn’t Going to Slow Me Down.- 80. Her Patients Never Wake Up On Time.- 81. When Enough Is Now Too Much.- 82. The Distressed Daughter.- 83. Check Check and D