More Details about Adaptive Design Theory And Implementation Using Sas And R, 2nd Edition

General Information  
Author(s)Chang and Mark
PublisherT and F CRC
Publish YearJanuary 2015


Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials. Covering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with up-to-date details on this innovative area in pharmaceutical research and development. Practitioners will be able to improve the efficiency of their trial design, thereby reducing the time and cost of drug development.

Key Features:-

  • Twelve new chapters covering blinded and semi-blinded sample size reestimation design, pick-the-winn
  • More analytical methods for K-stage adaptive designs, multiple-endpoint adaptive design, survival mo
  • New material on sequential parallel designs with rerandomization and the skeleton approach in adapti
  • Twenty new SAS macros and R functions
  • Enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered i