Description
Humana Alzheimers Disease A Physicians Guide To Practical Management by Ralph W. Richter , Brigitte Zoeller Richter , John P. Blass
This concise practical guide to the evaluation, assessment, and treatment of individuals with Alzheimer's disease also illuminates the basic neurobiologybiology underlying the disease and emerging therapeutic and promising preventive possibilities. On the clinical side, the authors focus on such issues as early changes and preclinical conditions - including mild cognitive impairment and predementia AD, how the patient presents, the therapy, and the recent neuropsychiatric treatment and behavioral aspects of AD. On the practical side, guidance is offered to medical providers and caregivers on the deep feelings of isolation, loneliness, and despair that the illness can create, and on how to overcome the consequent breakdown in communication. Part I. Scientific Background of Alzheimer's Disease Genetics of Alzheimer's Disease and Related Disorders John Hardy Neuropathology of Alzheimer's Disease Christian Schultz, Kelly Del Tredici, and Heiko Braak Oxidative Stress in the Development of Alzheimer's Disease and Other Dementias Domenico Pratico Metabolism and Alzheimer's Disease John P. Blass Part II. Epidemiology Alzheimer's Disease: Epidemiological and Statistical Data Brigitte Zoeller Richter and Ralph W. Richter The Economic Burden of Alzheimer's Disease and Dementia Anders Wimo and Bengt Winblad Potential and Established Risk Factors for Alzheimer's Disease Brigitte Zoeller Richter Part III. Clinical Assessment Medical Diagnosis and Workup of Alzheimer's Disease Ralph W. Richter Neuroimaging Techniques: CT, MRI, SPECT, PET Norman L. Foster Biological Markers in Alzheimer's Disease Ramon Diaz-Arrastia and Fred Baskin The Neuropsychology of Alzheimer's Disease Kirsten I. Taylor and Andreas U. Monsch Vascular Cognitive Impairment in Clinical Practice Kenneth Rockwood and Timo Erkinjuntti Lewy Body Disease Robert Barber, Jane Newby, and Ian G. McKeith Frontotemporal Lobe Dementia Malgorzata Franczak, Diana Kerwin, and Piero Antuono Part IV. The Transitional Stage Mild Forgetfulness: Distinguishing Early AD from Normal Aging Scott A. Small Mild Cognitive Impairment: What the Physician Should Know Brigitte Zoeller Richter Diagnosis of Predementia AD in a Clinical Setting Pieter Jelle Visser Loss of Olfactory Function in Patients With Alzheimer's Disease Claire Murphy and Paul E. Gilbert Part V. Treatment Options Treatment of Alzheimer's Disease: Basic Considerations Brigitte Zoeller Richter and Ralph W. Richter Donepezil in Treatment of AD Ging-Yuek Robin Hsiung and Howard Feldman Rivastigmine for Treatment of AD Martin R. Farlow Galantamine in Treatment of AD M. Saleem Ismail and Pierre N. Tariot Memantine in Treatment of AD Hans Jorg Mobius Alternative Treatment Options Brigitte Zoeller Richter Part VI. Late-Stage Therapy Pain and Palliative Care in Late-Stage Dementia Patients Sophie Pautex, Dina Zekry, Gilbert Zulian, Gabriel Gold, and Jean-Pierre Michel Cardiological Issues in Late-Stage Alzheimer's Disease: A Clinician's Approach Jose R. Medina Part VII. Prevention Strategies Neuroprotection and Neurodegenerative Disease Frank John Emery Vajda Neurotrophic Factors for Prevention of Alzheimer's Disease Mark H. Tuszynski Statins in Prevention and Treatment of Alzheimer's Disease David A. Drachman Potential Role of Androgens and Androgen Receptors in Alzheimer's Disease Jacob Raber Role of Nutrition in Prevention or Delay of Alzheimer's Disease Hannes B. Staehelin Impact of Physical Activity on Prevention of Alzheimer's Disease Danielle Laurin, Rene Verreault, and Joan Lindsay Part VIII. Future Developments Stem Cell Therapy for Alzheimer's Disease Kiminobu Sugaya Secretases as Potential Targets for Treatment of Alzheimer's Disease Weiming Xia AMPA Potentiation as a Treatment Option for Alzheimer's Disease Amy S. Chappell and Michael M. Witte Glycosaminoglycans as Potential Future Treatment of Alzheimer's Disease Umberto Cornelli Implications of Research for Management of AD Peter J. Whitehouse Part IX. Treatment Outcome Measurement Rating Scales and Outcome Variables Used in Clinical Trials Lon S. Schneider Part X. Neuropsychiatric Management Gender Differences in Behavior of AD Patients Brian R. Ott Management of Emotional and Behavioral Symptoms in AD Myron F. Weiner Assessment and Treatment of Neuropsychiatric Symptoms in Alzheimer's Disease Andrew R. Gustavson and Jeffrey L. Cummings Neuropsychiatric Symptoms in African American Dementia Patients Raymelle Schoos, Carl I. Cohen, and Lorna Walcott-Brown Resource Utilization by African American Dementia Patients Beatrice Pollock Apathy in Alzheimer's Disease: Relationship to Executive Function Susan McPherson Are Alzheimer's Patients Aware of Their Deficits? Ben Seltzer Part XI. Family and Care Issues Diagnostic Family Conference in AD: Issues and Recommendations Paul Michael Ramirez, David Castro-Blanco, and Michelle Kehn Care, Caregiver Issues, and Communication With the Demented Patient Ralph W. Richter and Brigitte Zoeller Richter Dental Care of AD Patients Christina A. Gitto, Michael J. Moroni, Geza T. Terezhalmy, and Satinderpal K. Sandu Long-Term Medical Care Issues Vonda K. Gravely and Jacobo Mintzer Loneliness and Depression in Caregivers Rose A. Beeson Frequently Asked Questions About Alzheimer's Disease Brigitte Zoeller Richter Appendix: Resources Index