Description
Wiley-VCH Verlag GmbH Analogue-Based Drug Discovery by Iupac , Janos Fischer
The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds. Of the 19 analog classes presented in detail, 9 are described by the scientists who discovered them. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability. 1. Advances in Probe Design for Protein NMR. 2. Diffusion in Soft Polymer Systems as Approached by Field Gradient NMR. 3. How Far Can the Sensitivity of NMR be Increased? 4. Applications of Low-Field NMR to Food Science. 5. Residual Dipolar Couplings: Measurements and Applications to Biomolecular Studies.