Androgen Excess Disorders In Women by Ricardo Azziz , Humana Press Inc.

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Humana Press Inc. Androgen Excess Disorders In Women by Ricardo Azziz

The field of androgen excess disorders has advanced substantially since the original publication of this book. The Androgen Excess Society (AES) was founded to bring together investigators in the field. A better understanding of the screening, progression, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has improved the clinical care and diagnostic accuracy of these patients. New criteria for the diagnosis of the polycystic ovary syndrome (PCOS) were proposed in Rotterdam, criteria that have resulted in controversy and, hopefully, initiation of new studies. The association of insulin resistance with PCOS has been strengthened, and the role of metformin in tre- ing the infertility of the PCOS has been validated. Risks for diabetes and, more cont- versially, cardiovascular disease in women with PCOS have received substantial investigation. Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance. These are but a few highlights of how the terrain has changed in a relatively brief period of time. In keeping with these advances, the title of this book has been revised to reflect the growing importance of PCOS as the most prevalent androgen excess disorder in women, and arguably, as the one that might have the most serious adverse consequences for general health. There are fewer chapters to provide a more focused elucidation of the area. Several chapters were penned by new (and young) authors who are conducting cutting-edge research in the field._x000D_ _x000D_ I. Introduction_x000D_ _x000D_ A Brief History of Androgen Excess_x000D_ Ricardo Azziz_x000D_ _x000D_ II. Physiology of Androgens_x000D_ _x000D_ Ovarian and Adrenal Androgen Biosynthesis and Metabolis_x000D_ Walter L. Miller, David H. Geller, and Mitchell Rosen_x000D_ _x000D_ Androgens Throughout the Life of Women_x000D_ C. Richard Parker, Jr._x000D_ _x000D_ Physiologic Effects of Androgens in Women_x000D_ T. Keta Hodgson and Glenn D. Braunstein_x000D_ _x000D_ Androgen Measurements: Methods, Interpretation and Limitations_x000D_ Frank Z. Stanczyk_x000D_ _x000D_ III. Pathophysiology of Androgen Excess_x000D_ _x000D_ Androgen-Secreting Adrenal and Ovarian Neoplasms_x000D_ Michel Pugeat, Gerald Raverot, Ingrid Plotton, Aude Brac de la Perriere, Pascale Mirakian, Henri Dechaud, Nicole Berger, and Jean Louis Peix_x000D_ _x000D_ Cushing's Syndrome Acromegaly and Androgen Excess_x000D_ Anne-Celine REYSS, Didier Dewailly_x000D_ _x000D_ The Non Classic Adrenal Hyperplasias_x000D_ Didier Dewailly and Ricardo Azzizb_x000D_ _x000D_ Pregnancy-Related Androgen Excess_x000D_ Howard D. McClamrock_x000D_ _x000D_ Drug-Induced Hyperandrogenism_x000D_ Christine Cortet-Rudelli and Didier Dewailly_x000D_ _x000D_ The Severe Insulin Resistant Hyperandrogenic Syndromes_x000D_ David E. Moller, Antonio Vidal-Puig, and Ricardo Azziz_x000D_ _x000D_ Idiopathic Hirsutism_x000D_ Enrico Carmina_x000D_ _x000D_ Definition and Epidemiology of the Polycystic Ovary Syndrome_x000D_ Ricardo Azziz_x000D_ _x000D_ Clinical Features of PCOS_x000D_ W. Futterweit, E. Diamanti-Kandarakis, and Ricardo Azziz_x000D_ _x000D_ Biochemical Features of the Polycystic Ovary Syndrome_x000D_ Adam Balen_x000D_ _x000D_ Ovarian Histology, Morphology and Ultrasonography in PCOS_x000D_ Sophie Jonard, Yann Robert, Yves Ardaens, and Didier Dewailly_x000D_ _x000D_ Hypothalamic-Pituitary-Gonadotropic Dysfunction in PCOS_x000D_ R. Jeffrey Chang and Rinku V. Mehta_x000D_ _x000D_ Ovarian Steroidogenic Abnormalities in PCOS_x000D_ Denis A. Magoffin_x000D_ _x000D_ Hypothalamic-Pituitary Adrenal Dysfunction in Polycystic Ovary Syndrome_x000D_ Bulent O.Yildiz, Enrico Carmina, and Ricardo Azziz_x000D_ _x000D_ The Genetic Basis of Polycystic Ovary Syndrome_x000D_ Mark O. Goodarzi_x000D_ _x000D_ Pediatric Hyperandrogenism_x000D_ Kathleen M. Hoeger_x000D_ _x000D_ Environmental Factors in the Polycystic Ovary Syndrome_x000D_ Marie-France Hivert and Jean-Patrice Baillargeon_x000D_ _x000D_ Animal Models and Fetal Programming of PCOS_x000D_ David H. Abbott, Daniel A. Dumesic, Jon E. Levine, Andrea Dunaif, and Vasantha Padmanabhan_x000D_ _x000D_ Insulin Resistance and Hyperinsulinism in PCOS_x000D_ Paulina A. Essah and John E. Nestler_x000D_ _x000D_ The Endocrine Impact of Obesity and Body Habitus in PCOS_x000D_ Pasquali Renato and Gambineri Alessandra_x000D_ _x000D_ Molecular Mechanisms of Insulin Resistance in PCOS_x000D_ Theodore P. Ciaraldi_x000D_ _x000D_ Menstrual Dysfunction and Endometrial Neoplasia_x000D_ Abdulkadir Wagley and Paul Hardiman_x000D_ _x000D_ Beta Cell Dysfunction, Glucose Intolerance, and Diabetes in PCOS_x000D_ David A. Ehrmann_x000D_ _x000D_ Hypertension, and Cardiovascular and Lipoprotein Abnormalities_x000D_ Francesco Orio and Stefano Palomba_x000D_ _x000D_ Reproductive and Obstetrical Consequences of Polycystic Ovary Syndrome_x000D_ Mary C. Johnson and Richard S. Legro_x000D_ _x000D_ Psychosocial and Quality-of-Life Consequences of Androgen Excess_x000D_ Onno E. Janssen, Susanne Hahn, and Sigrid Elsenbruch_x000D_ _x000D_ Overview of Long-Term Morbidity and Economic Cost of PCOS_x000D_ Ricardo Azziz_x000D_ _x000D_ IV. Evaluation and Treatment of Androgen Excess_x000D_ _x000D_ Clinical and Hormonal Evaluation of Androgen Excess_x000D_ Ricardo Azziz_x000D_ _x000D_ Ovarian Suppression and Treatment of Hirsutism_x000D_ Paolo Moghetti_x000D_ _x000D_ Polycystic Ovary Syndrome and Ovulation Induction_x000D_ Bulent O. Yildiz and Ricardo Azziz_x000D_ _x000D_ In Vitro Fertilization for Polycystic Ovary Syndrome_x000D_ Hanadi Ba-Akdah, Ezgi Demirtas, Hananel Holzer, William Buckett, and Seang Lin Tan_x000D_ _x000D_ The Surgical Management of Polycystic Ovary Syndrome_x000D_ Adam Balen_x000D_ _x000D_ Use of Insulin Sensit_x000D_