Description
COLD SPRING HARBOR LABORATORY PRESS Angiogenesis Biology and Pathology by Michael Klagsbrun Patricia A. D'more
Angiogenesis is the process by which new blood vessels are generated from preexisting vessels. It is vital for proper embryonic development, patterning of the vascular system, and wound healing. It is rate limiting in cancer progression, because the formation of new blood vessels is essentialfor growth and survival of tumors. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer. The contributors review the biology of endothelial cells, describing the specificroles of tip and stalk cells in vessel sprouting and lumen formation. They discuss the key angiogenic regulators (e.g., vascular endothelial growth factor [VEGF]), as well as antiangiogenic agents including microRNAs, thrombospondins, and semaphorins. Therapeutic approaches that target pathologicalangiogenesis, such as the ongoing clinical trials of anti-VEGF drugs, are also covered. This volume, which includes discussions of other vascular dysfunctions (e.g., arteriovenous malformations) and comparisons between the blood vascular system and the lymphatic system, is a vital reference fordevelopmental and cancer biologists, as well as anyone seeking to understand the biology and pathology of the vascular system. Preface; 1. Globalization and the multinational corporation; Part I. Introduction to Foreign Exchange Markets and Risks: 2. The foreign exchange market; 3. Forward markets and transaction exchange risk; 4. The balance of payments; 5. Exchange rate systems; Part II. International Parity Conditions and Exchange Rate Determination: 6. Interest rate parity; 7. Speculation and risk in the foreign exchange market; 8. Purchasing power parity and real exchange rates; 9. Measuring and managing real exchange risk; 10. Exchange rate determination and forecasting; Part III. International Capital Markets: 11. International debt financing; 12. International equity financing; 13. International capital market equilibrium; 14. Country and political risk; Part IV. International Corporate Finance: 15. International capital budgeting; 16. Additional topics in international capital budgeting; 17. Risk management and the foreign currency hedging decision; Part V. Managing Ongoing Operations: 18. Financing international trade; 19. Managing net working capital; Part VI. Foreign Currency Derivatives: 20. Foreign currency futures and options; 21. Interest rate and foreign currency swaps; Glossary; Index.