Springer Insulin Resistance Childhood Precursors of Adult Disease edited by Zeitler, Philip S., Nadeau, Kristen J. (Eds.)

Contemporary Endocrinology (Pediatric Endocrinology) . The book is promoting new points of view and creative approaches to the clinicians and researchers who are facing daunting challenges to build perspective on issues of insulin resistance in youth, an emerging risk factor for disease across the lifespan.  Its a revised and updated edition of the classic 2008 text on insulin resistance in the pediatric population and its impact across the lifespan.

The book discusses epidemiology, pathophysiology, molecular and metabolic mechanisms, unique models and management strategies for insulin resistance, as well as its relationship with cardiovascular and liver disorders. It Includes chapters specifically on insulin resistance in patients with type 1 diabetes, children born small for their age and girls with polycystic ovary syndrome.

The second section of the book explores pathophysiology, including current knowledge of the molecular, metabolic, and physiologic mechanisms of insulin resistance, the unique pathophysiology of pregnancy and puberty, the contributions of the prenatal and early childhood environment to the development of insulin resistance, and adipose and biochemical mediators.

The third section, new to this second edition, explores insulin resistance in unique models: intrauterine growth restriction and girls with polycystic ovary syndrome and metabolic syndrome.

The final section of the book explores the concepts of treatment through medications directed at insulin sensitivity, as well as exercise, weight loss medications and consequences of bariatric surgery.

Know your author

Philip S. Zeitler, MD, PhD, is a Professor and Head of Department of Pediatrics-Endocrinology, University of Colorado School of Medicine. He is a Medical Director of  Children’s Hospital Colorado, Aurora, CO, USA. Also serves as the President-Elect of the Pediatric Endocrine Society and Editor-in-Chief of Pediatric Diabetes. Dr. Zeitler’s research group focuses on understanding obesity, insulin resistance, and diabetes in adolescence.

Kristen J. Nadeau, MD, MS, is an Associate Professor in the Department of Pediatrics-Endocrinology, University of Colorado School of Medicine. She is also associated with Children’s Hospital Colorado, Aurora, CO, USA

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