Calming The Brain: Benzodiazepines And Related Drugs From Laboratory To Clinic at Meripustak

Calming The Brain: Benzodiazepines And Related Drugs From Laboratory To Clinic

Books from same Author: Ian Martin and David J Nutt and Adam Doble

Books from same Publisher: Taylor & Francis

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  • General Information  
    Author(s)Ian Martin and David J Nutt and Adam Doble
    PublisherTaylor & Francis
    ISBN9781841840529
    Pages192
    BindingHardbound
    LanguageEnglish
    Publish YearMarch 2004

    Description

    Taylor & Francis Calming The Brain: Benzodiazepines And Related Drugs From Laboratory To Clinic by Ian Martin and David J Nutt and Adam Doble

    This book covers the entire field of research in the area of minor tranquillizers and its application to current clinical practice in the treatment of anxiety and insomnia. These drugs are principally the benzodiazepines and related drugs with a similar mechanism of action, such as zolpidem and zopiclone. The molecular mechanism of action of benzodiazepines is described, focussing on the interaction of these drugs with the different isoform of the GABAA^O receptor, and the consequences of this for brain function. Recent advances in this knowledge have provided a framework for defining the physiochemical nature of the interaction between such drugs and their receptor protein, and thus pave the way for the design of new anxiolytic and hypnotic drugs. The animal models available for evaluating the potential of such new therapeutic agents in the treatment of anxiety and insomnia are discussed. Furthermore, understanding of the physiological regulation of the GABAA receptor may provide insights into the aetiopathology of these diseases. The clinical use of benzodiazepines and related drugs in the treatment of anxiety, insomnia, epilepsy and as anaesthetics are explored. The advantages and limitations of such treatments are discussed, and the impact of drugs evaluated. A chapter is devoted to the issue of independence, the clinical pertinence of tolerence