Description
Kluwer Academic Current Perspectives In Hepatology Festschrift For Hyman J.Zimmerman M.D. 1989 Edition by Leonard B. Seeff James H. Lewis
Based on a symposium held in Bethesda Maryland Spring 1987. A collection of articles on liver disease emphasizing Zimmerman's combined clinical and pathologic approach each author offering his own particular expertise within the field. Major sections are viral hepatitis chronic liver disease (including cirrhosis) toxic liver injury metabolic and infectious diseases and miscellaneous diseases (including liver disease of pregnancy). Annotation copyright Book News Inc. Portland Or. Table of contents : I Basics of the CPBS Approach to Risk Assessment and Decision Making.- 1 The Carcinogenicity Prediction and Battery Selection Approach.- 1.1. Introduction.- 1.2. Overview of the CPBS Methodology.- 1.3. The Cancer Hazard Identification Problem.- References.- 2 Fundamental Basics of the CPBS Approach.- 2.1. Bayesian Decision Analysis.- 2.2. Cluster Analysis.- 2.3. Multiple-Objective Decision Making.- 2.4. Dynamic Programming.- References.- II Carcinogenicity Prediction and Battery Selection Methodology.- 3 Preliminary Analysis.- 3.1. Data Base Considerations.- 3.2. Analysis of Test Performance.- 3.3. Exploratory Analysis of the Data.- 3.4. Testing for Dependencies among Tests.- References.- 4 Battery Selection.- 4.1. Computing Measures of Battery Performance.- 4.2. Battery Selection Using Enumeration.- 4.3. A Heuristic Approach for Constructing Batteries with Good Performance.- 4.4. A Strategy for Constructing Batteries Using Dynamic Programming.- 4.5. Dynamic Programming for Construction of Non-dominated Batteries.- References.- 5 Risk Assessment Using Test Results.- 5.1. Making Predictions When Tests Are Conditionally Independent.- 5.2. Making Predictions When Tests Are Conditionally Dependent.- Reference.- 6 Applications of CPBS to Cancer Hazard Identification.- 6.1. Introduction.- 6.2. An Illustration of CPBS Prediction on Acrylamide.- 6.3. Battery Selection Considerations.- 6.4. CPBS and Decision Analysis.- 6.5. Closing Remarks.- References.- Epilogue.- Appendix. List of Abbreviations for Bioassays and Short-Term Tests.