More Details about Design And Analysis Of Clinical Trials For Predictive Medicine

General Information  
Author(s)Marc Buyse and Richard Simon and Shigeyuki Matsui
PublisherTaylor & Francis
ISBN9781466558151
Pages400
BindingHardbound
LanguageEnglish
Publish YearMarch 2015

Description

Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics-from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials. The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving.