Description
Taylor & Francis Drug Transport in Antimicrobial and Anticancer Chemotherapy 1995 Edition by N Georgopapadakou, Georgopapadakou
Providing contributions drawn from experts specialties of medicine, medical microbiology, pharmacology, therapeutics, medical oncology, infectious disease, biochemistry, molecular biology, and cell biology, this book explores drug transport and its role in resistance in antimicrobial and cancer chemotherapy. The book establishes the biochemical and clinical framework for a diverse audience and focuses specifically on the transport of antibacterial, antifungal/antiparasitic , and anticancer agents. It includes several tables, graphs, and drawings to illustrate appropriate data and convey complex ideas and provides a thorough overview of material not covered in sufficiently in clinical texts. Table of contents :- Clinical Significance of Antibacterial Transport; The Impact of Transport-Associated Resistance in Anticancer Chemotherapy; Composition and Properties of Cellular Membranes; Mechanisms of Drug Transport in Prokaryotes and Eukaryotes; Beta-LactamPermeation; Aminoglycoside Transport; Tetracycline Uptake and Efflux in Bacteria; Quinolone Uptake and Efflux Antibiotic Transport in Mycobacteria; Bacterial Transport as an Import Mechanism and Target for Antimicrobials; Internalization of Amphotericin Band Other Polyene Antifungals in Mammalian Cells - A Possible Origin of Their Toxicity; Azole Antifungals; Chloroquine Transport in the Malarial Parasite Plasmodium falciparum; Transport of Antifolates and Antimonials in Drug-Resistant Leishmania;Nucleoside Transport; Mechanisms of Receptor-Mediated Folate and Antifolate Membrane Transport in Cancer Chemotherapy; Cellular and Biochemical Aspects of Multidrug Resistance; Modulation of Multidrug Resistance in Tumor Cells; Glutathione Conjugation andATP-Dependent Export of Anticancer Drugs; Circumventing Transport-Associated Resistance Through Drug Delivery.