Description
Springer Essentials of Blood Product Management in Anesthesia Practice 2021 Edition by Corey S. Scher, Alan David Kaye, Henry Liu, Seth Perelman, Sarah Leavitt
This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice.Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers. Table of contents: The History of Blood TransfusionsModern Blood BankingComponent Therapy and Whole Blood: Packed Red Blood Cells, Fresh Frozen Plasma, Cryoprecipitate, washed and or radiated red cellsThe Coagulation System and Clot StabilityFibrinolysis- Tranexamic Acid and Aminocaproic Acid.Hypercoagulation and Thrombotic Disorders: TTP, Factor 5 Leiden, Phospholipid Syndrome, Anti-thrombin 3, hypereosinophils, oxidative stress, cancer.Diseases or Conditions of Platelet DysfunctionThe Massive Transfusion ProtocolNew Biologicals to Assist Clotting- Riastap, Prothrombin Concentrates. Antithrombin3, Fibrogammin and factor13, Fibrosupernatant, Fibrinogen Concentrates, Recombinant Factor 7, DDAVP, Octaplast G., Factor 10A, KCentraBiologicals that Inhibit Clot generation -The Heparins, Factor 10A inhibitors, rivaroxaban, apixaban, dabigatran,Point of Care Testing and Goal Directed Therapy- Thromboelastography, ROTEM, Platelet function analyzer, stat-PT, thrombin generation assays, multi-electro-aggregometry, OHP (Overall hemostatic potential assay), ACT.Complications of Blood Transfusions: TRALI, TACO, Blood type mismatch, infectionDiseases of the Coagulation System- Hemophilia, VonWillebrand Disease, Cryoglobulinemia, Inborn Errors of Factor SynthesisBlood Conservation Strategies and Bloodless Surgery- normovolemic hemodilution, cell saver,Bridges to Transfusion when blood is not immediately available.Artificial BloodPreoperative correction of anemiaBlood Deployment in Natural Disasters and the Military in CombatCommonly prescribed medications that affect clotting-anti-depressants, NSAIDS, ASAAnesthesia for the severe trauma patient- new evidence from new trialsOld blood vs. new blood- Is storage injury a concern?Vascular Endothelial dysfunction and inflammatory statesLiberal or restrictive blood transfusions