Description
Taylor & Francis Ltd Fundamentals Of Modern Bioprocessing 2017 Edition by Sarfaraz K. Niazi, Justin L. Brown
Biological drug and vaccine manufacturing has quickly become one of the highest-value fields of bioprocess engineering, and many bioprocess engineers are now finding job opportunities that have traditionally gone to chemical engineers. Fundamentals of Modern Bioprocessing addresses this growing demand. Written by experts well-established in the field, this book connects the principles and applications of bioprocessing engineering to healthcare product manufacturing and expands on areas of opportunity for qualified bioprocess engineers and students. The book is divided into two sections: the first half centers on the engineering fundamentals of bioprocessing; while the second half serves as a handbook offering advice and practical applications.Focused on the fundamental principles at the core of this discipline, this work outlines every facet of design, component selection, and regulatory concerns. It discusses the purpose of bioprocessing (to produce products suitable for human use), describes the manufacturing technologies related to bioprocessing, and explores the rapid expansion of bioprocess engineering applications relevant to health care product manufacturing. It also considers the future of bioprocessing-the use of disposable components (which is the fastest growing area in the field of bioprocessing) to replace traditional stainless steel. In addition, this text:Discusses the many types of genetically modified organismsOutlines laboratory techniquesIncludes the most recent developmentsServes as a reference and contains an extensive bibliography Emphasizes biological manufacturing using recombinant processing, which begins with creating a genetically modified organism using recombinant techniquesFundamentals of Modern Bioprocessing outlines both the principles and applications of bioprocessing engineering related to healthcare product manufacturing. It lays out the basic concepts, definitions, methods and applications of bioprocessing. A single volume comprehensive reference developed to meet the needs of students with a bioprocessing background; it can also be used as a source for professionals in the field. ENGINEERING FUNDAMENTALS OF BIOPROCESSINGFrontiers of BioprocessingDefining BioprocessingCurrent and Emerging Trends in Bioprocess EngineeringMaterials AdvancesNanoscale AdvancesBioprocessing for Chemical and Biologic Product ManufacturingBioprocessing Leaders WorldwideEconomic Predictions and Careers in Bioprocess EngineeringSkills Needed for Future Bioprocess EngineersAppendix A: A Time Line of Biotechnology DevelopmentIntroduction to Molecular BiologyIntroductionBuilding Blocks of Life: DNA, RNA, and ProteinsDNA ReplicationTranscriptionTranslationGenesMutationsChromosomeDNA CloningIntroduction to BiochemistryIntroductionDNA StructureRNA StructureProtein Structure and FunctionCarbohydratesLipids, Fats, and SteroidsBasic Metabolic PathwaysIntroduction to Cellular MicrobiologyIntroductionGeneral Cell StructureEukaryotes, Prokaryotes, Archaea, and VirusesIntracellular OrganellesCellular TransportIntracellular Signal TransductionReaction Stoichiometry, Thermodynamics, and KineticsIntroductionMass and Energy BalancesFundamentals of Chemical ReactionsBasic Mass Transfer: Diffusion and ConvectionBasic Fluid DynamicsBasic ThermodynamicsBasic Reaction KineticsKinetics of Enzymes and Cell GrowthIntroductionBasic Michaelis-Menten KineticsMichaelis-Menten Kinetics with InhibitionpH and Transport LimitationsOther Enzyme KineticsProkaryotic and Eukaryotic Growth ModelsAdvanced Prokaryotic and Eukaryotic Growth ModelsData ManagementIntroductionGood Laboratory PracticesElectronic Data HandlingData ErrorsStatistical AnalysisData ConclusionsFlow DiagramsExercises and SolutionsHANDBOOK OF BIOPROCESSINGElements of BioprocessingIntroductionUpstream ProcessingBioreactorDownstream ProcessingGenetically Modified OrganismsIntroductionCell Line CharacterizationCharacterization of Cell and Virus BanksCell Line ConstructionDesigning GMCSVectorHost SystemsExpression System in E ColiConfiguration of Efficient Expression VectorsProtein ProductionGenetic Manipulations to Improve YieldManufacturing OverviewIntroductionCell Culture Expression SystemsTransgenic AnimalsCell Lines and CharacterizationMediaCulture GrowthExtraction, Isolation, and PurificationCapturePurificationImpurity RemovalValidationIntermediate PurificationPolishingFormulationProcess OverviewTech Transfer and DocumentationValidationScale UpSpecific Economy IssuesProcess MaterialsEnvironment ControlGood Manufacturing Controls of Active Pharmaceutical IngredientsManufacturing Systems and LayoutCleaning ProceduresProcessing and FillingLaboratory TestingLaboratory ControlsDocumentationTechnical PackageOutsourcing in Biotech ManufacturingIssues to DiscussDisposable Bioprocessing SystemsIntroductionSafety of Disposable SystemsRegulatory MattersRisk AssessmentDisposable ContainersTank LinersMixing SystemsDisposable BioreactorsDisposable Connectors and TransfersDisposable Control and Monitoring SystemsDownstream ProcessingFiltrationUpstream ProcessingIntroductionBioreactorsBatch CultureContinuous CultureFed-Batch CulturePerfusion CultureSuspension CultureMicrocarrier SupportRoller Bottle Culture SystemSpinner Flask CultureOther Scale up OptionsWave BioreactorCell Cube TechnologyRotary Culture SystemMediaScaling and Production CostsProblem Resolution in Fusion Protein ExpressionDownstream ProcessingIntroductionCaptureSystem SuitabilityDownstream Processing SystemsProcess FlowPurificationIntroductionProtein PropertiesAffinity ChromatographyImmobilized Metal Affinity ChromatographyAnion Exchange ChromatographyCation Exchange ChromatographySize Exclusion ChromatographyReversed Phase ChromatographyHydroxyapatite ChromatographyHydrophobic Interaction ChromatographyScale-up and OptimizationManufacturing SystemsBacterial Expression SystemsGenetically Modified BacteriaMammalian Cells Manufacturing SystemsYeast Cell Expression SystemInsect Cells SystemsQuality ConsiderationIntroductionManagement ResponsibilitiesResourcesManufacturing OperationsEvaluation ActivitiesConclusionQA SystemsValidation Master PlanRaw MaterialsColumn LifeProcessVirus ValidationTesting of ProductIn-Process ControlRegulatory AffairsRegulatory IssuesProtein DegradationStability ConsiderationsIntellectual PropertyIntroductionPatenting Systems and StrategiesThe Patent LawsTypes of Patent LawsAnatomy of a PatentPatentabilityPatentability and Technical Information SearchComponents of a Patent ApplicationInventions of Interest to Pharmaceutical ScientistsBiotechnology InventionsPatenting StrategiesBibliography