Description
John Wiley Genetic Disorders And The Fetus Diagnosis Prevention And Treatment 8Ed (Hb 2021) by Milunsky A.
Explore the latest edition of the definitive resource on prenatal genetic diagnosis In the newly revised eighth edition of Genetic Disorders and the Fetus, authors and acclaimed medical doctors, Aubrey and Jeff Milunsky, deliver a thorough and comprehensive reference perfect for academicians, students in post-graduate specialization courses, and working medical professionals. This book incorporates the knowledge, wisdom, perspectives, and recommendations from a renowned team of contributing authors, drawing upon their extensive experience in prenatal genetic diagnosis to present the definitive reference work used routinely around the world. In addition to fundamental information on established prenatal diagnosis and exhaustively referenced coverage of new techniques, you'll find new chapters on preconception genetic counselling, preimplantation genetic diagnosis, advances in fetal imaging, and gene therapy. Genetic Disorders and the Fetus is authored by a global team of internationally recognized contributors, all of whom are leading voices in the field The eighth edition also contains: A thorough discussion of the public policy and ethics of embryo editing, including mitochondrial replacement treatment, and gene patents, prenatal diagnosis, and polygenic disease risk prediction An exploration of preimplantation genetic diagnosis, pharmacogenetics and prenatal diagnosis, and whole genome sequencing A treatment of genetic disorders and pharmacologic therapy, including spinal muscular atrophy and fragile X syndrome A discussion of legal issues, including the fetus as plaintiff and the increasing liability of physicians due to advances in genetics Perfect for obstetricians, clinical geneticists, molecular and biochemical geneticists, and pediatricians, Genetic Disorders and the Fetus will also earn a place in the libraries of neonatologists, genetics counsellors, ethicists, radiologists, and professionals working in public policy and health departments. Preface ixAcknowledgments xiiiContributors xv1 Genetic Counseling: Preconception, Prenatal, and Perinatal 1Aubrey Milunsky and Jeff M Milunsky2 PreimplantationGenetic Testing 102Anver Kuliev and Svetlana Rechitsky3 Amniotic Fluid Constituents, Cell Culture, andNeural TubeDefects 140Daniel L Van Dyke and Aubrey Milunsky4 Molecular Aspects of PlacentalDevelopment 197Wendy P Robinson and Deborah E McFadden5 FetalOrigins of AdultHealth andDisease .214Michael G Ross and Mina Desai6 Maternal SerumScreening for Chromosomal Abnormalities andNeural TubeDefects 240Howard Cuckle7 Noninvasive Screening for AneuploidyUsing Cell-Free PlacentalDNA 301Lorraine Dugoff8 Noninvasive Prenatal Diagnosis and Screening for Monogenic Disorders Using Cell-Free DNA 318Ignatia B Van den Veyver, Natalie Chandler and Lyn S Chitty9 Amniocentesis, ChorionicVillus Sampling, and Fetal Blood Sampling .346Anthony O Odibo10 PrenatalDiagnosis ofNeural TubeDefects 375Aubrey Milunsky11 Prenatal Diagnosis of Chromosomal Abnormalities through Chorionic Villus Sampling and Amniocentesis 404Peter A Benn12 PrenatalDiagnosis of Sex Chromosome Abnormalities 499Jeff M Milunsky13 PrenatalDiagnosis of Chromosomal Abnormalities: FromKaryotype toMicroarray 547Brynn Levy14 MolecularGenetics and PrenatalDiagnosis 572Jeff M Milunsky15 PrenatalDiagnosis of Cystic Fibrosis 611Wayne W Grody16 PrenatalDiagnosis and the Spectrumof Involvement fromFragile XMutations 629Randi J Hagerman and Paul J Hagerman17 PrenatalDiagnosis of FetalMalformations byUltrasound .647Liesbeth van Leeuwen, Malou A Lugthart and Eva Pajkrt18 Prenatal Diagnosis and Management of Abnormal Fetal Development in theThird Trimester of Pregnancy 701Roland Axt-Fliedner and AlineWolter19 PrenatalDiagnosis by FetalMagnetic Resonance Imaging .760Nadine Girard and Kathia Chaumoitre20 PrenatalDiagnosis of SkeletalDysplasias and Connective TissueDisorders 783Andrea Superti-Furga and Sheila Unger21 PrenatalDiagnosis ofDisorders of CarbohydrateMetabolism 803Deeksha Sarihyan Bali, Stephanie L Austin and Priya S Kishnani22 Disorders ofMetabolismof Amino Acids and Related Compounds 831Andrea Gropman, Georgianne Arnold and Jerry Vockley23 The Mucopolysaccharidoses: Prenatal Diagnosis, Neonatal Screening and Emerging Therapies 868Lorne A Clarke24 Prenatal Diagnosis of the Peroxisomal and Mitochondrial Fatty Acid Oxidation Deficiencies 890Ronald J.A.Wanders and Hans R.Waterham25 PrenatalDiagnosis ofDisorders of LipidMetabolism 910James E Davison, Steven E Humphries, Bryan G.Winchester and Sara E Mole26 PrenatalDiagnosis of Primary ImmunodeficiencyDiseases 982Jennifer M Puck27 PrenatalDiagnosis of theHemoglobinopathies 1002John M Old and Jan Traeger-Synodinos28 PrenatalDiagnosis of InheritedDisorders of Folate and CobalaminMetabolism .1035David S Rosenblatt andDavidWatkins29 Fetal Surgery .1050Michael A Belfort and Alireza A Shamshirsaz30 In Utero StemCell Transplantation, Enzyme Replacement, andGeneTherapy 1105Tippi C MacKenzie andMarisa E Schwab31 MaternalGeneticDisordersThat Affect FetalHealth 1120Karin J Blakemore32 Pregnancy Termination forGeneticDisorders: Indications and Complications 1158Lee P Shulman33 Providing Supportive Psychosocial Care to Parents after Perinatal Loss 1179Marianne H Hutti34 PrenatalDiagnosis of Fetal Infection 1197Marianne Leruez-Ville, Valentine Faure-Bardon and Yves G Ville35 Medicolegal Aspects of PrenatalDiagnosis 1236EllenWright Clayton36 Prenatal and PreimplantationDiagnosis: International Policy Perspectives 1250Minh Thu Minh Nguyen and Bartha Maria Knoppers37 Ethical Issues in theDiagnosis andManagement ofGeneticDisorders in the Fetus 1267Frank A Chervenak and Laurence B McCulloughIndex 1294