Description
Springer Genetic Immunization 2000 Edition by Adrian Bot Constantin A. Bona
Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses bacteria and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy namely cancerous auto immune and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids. Table of contents : Preface. 1. Approaches for Development of New Vaccines. 2. Genetic Vaccination: Routes and Formulations. 3. Intrinsic Adjuvant Properties of Plasmid DNA. 4. Cellular Mechanisms Involved in the Immune Response Elicited by Genetic Immunization. 5. Protective Immune Responses Elicited by Genetic Immunization Against Viruses. 6. Immune Responses Elicited by Genetic Immunization with Bacterial or Parasite Antigens. 7. Autoimmunity Allergy and Genetic Vaccines. 8. Genetic Immunization Against Tumors. 9. Genetic Vaccination of Neonates. Index.