Harrison's Principles of Internal Medicine(Vol.1 and VOL.2) 20th Edition 2018 at Meripustak

Harrison's Principles of Internal Medicine(Vol.1 and VOL.2) 20th Edition 2018


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  • General Information  
    Author(s)J Larry Jameson and Anthony Fauci and Dennis Kasper and Stephen Hauser and Dan Longo and Joseph Loscalzo
    PublisherMcgraw-Hill
    Edition20th Edition
    ISBN9781259834806
    BindingHardbound
    LanguageEnglish
    Publish YearDecember 2018

    Description

    Mcgraw-Hill Harrison's Principles of Internal Medicine(Vol.1 and VOL.2) 20th Edition 2018 by J Larry Jameson and Anthony Fauci and Dennis Kasper and Stephen Hauser and Dan Longo and Joseph Loscalzo

    MASTER MODERN MEDICINE!
    Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

    The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms

    Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

    Essential for practice and education, the landmark 20th Edition features:

    Thoroughly revised content?covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison's. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.
    State-of-the-art coverage of disease mechanisms: Harrison's focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison's summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system's role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.
    All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine? Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.
    Important and timely new chapters'such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more?offer the very latest, definitive perspectives on must-know topics in medical education and practice. 
    Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.
    End-of-chapter suggested readings reinforc

    Table of Contents:- 
    CONTRIBUTORS
    PREFACE
    Part 1: The Profession of Medicine
     
    1 The Practice of Medicine
    The Editors

    2 Promoting Good Health
    Donald M. Lloyd-Jones, Kathleen M. McKibbin

    3 Decision-Making in Clinical Medicine
    Daniel B. Mark, John B. Wong

    4 Screening and Prevention of Disease
    Katrina A. Armstrong, Gary J. Martin

    5 Health Care Systems in Developed Countries
    Richard B. Saltman

    6 The Safety and Quality of Health Care
    David W. Bates

    7 Racial and Ethnic Disparities in Health Care
    Joseph R. Betancourt, Alexander R. Green

    8 Ethical Issues in Clinical Medicine
    Bernard Lo, Christine Grady

    9 Palliative and End-of-Life Care
    Ezekiel J. Emanuel
     
    Part 2: Cardinal Manifestations and Presentation of Diseases
     
    Section 1: Pain
     
    10 Pain: Pathophysiology and Management
    James P. Rathmell, Howard L. Fields

    11 Chest Discomfort
    David A. Morrow

    12 Abdominal Pain
    Danny O. Jacobs

    13 Headache
    Peter J. Goadsby

    14 Back and Neck Pain
    John W. Engstrom
     
    Section 2: Alterations in Body Temperature
     
    15 Fever
    Charles A. Dinarello, Reuven Porat

    16 Fever and Rash
    Elaine T. Kaye, Kenneth M. Kaye

    17 Fever of Unknown Origin
    Chantal P. Bleeker-Rovers, Jos W. M. van der Meer
     
    Section 3: Nervous System Dysfunction
     
    18 Syncope
    Roy Freeman

    19 Dizziness and Vertigo
    Mark F. Walker, Robert B. Daroff

    20 Fatigue
    Jeffrey M. Gelfand, Vanja C. Douglas

    21 Neurologic Causes of "Weakness and Paralysis
    Michael J. Aminoff

    22 Numbness, Tingling, and Sensory Loss
    Michael J. Aminoff

    23 Gait Disorders, Imbalance and Falls
    Jessica M. Baker, Lewis R. Sudarsky

    24 Confusion and Delirium
    S. Andrew Josephson, Bruce L. Miller

    25 Dementia
    William W. Seeley, Bruce L. Miller

    26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral Disorders
    M.-Marsel Mesulam

    27 Sleep Disorders
    Thomas E. Scammell, Clifford B. Saper, Charles A. Czeisler
     
    Section 4: Disorders of Eyes, Ears, Nose, and Throat
     
    28 Disorders of the Eye
    Jonathan C. Horton

    29 Disorders of Smell and Taste
    Richard L. Doty, Steven M. Bromley

    30 Disorders of Hearing
    Anil K. Lalwani

    31 Sore Throat, Earache, and Upper Respiratory Symptoms
    Michael A. Rubin, Larry C. Ford, Ralph Gonzales

    32 Oral Manifestations of Disease
    Samuel C. Durso
     
    Section 5: Alterations in Circulatory and Respiratory Functions
     
    33 Dyspnea
    Rebecca M. Baron

    34 Cough 
    Christopher H. Fanta

    35 Hemoptysis
    Anna K. Brady, Patricia A. Kritek

    36 Hypoxia and Cyanosis
    Joseph Loscalzo

    37 Edema
    Eugene Braunwald, Joseph Loscalzo

    38 Approach to the Patient with a Heart Murmur
    Patrick T. O'Gara, Joseph Loscalzo

    39 Palpitations
    Joseph Loscalzo
     
    Section 6: Alterations in Gastrointestinal Function
     
    40 Dysphagia
    Ikuo Hirano, Peter J. Kahrilas

    41 Nausea, Vomiting, and Indigestion
    William L. Hasler

    42 Diarrhea and Constipation
    Michael Camilleri, Joseph A. Murray

    43 Unintentional Weight Loss
    J. Larry Jameson

    44 Gastrointestinal Bleeding
    Loren Laine

    45 Jaundice
    Savio John, Daniel S. Pratt

    46 Abdominal Swelling and Ascites
    Kathleen E. Corey, Lawrence S. Friedman
     
    Section 7: Alterations in Renal and Urinary Tract Function
     
    47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain Syndrome
    John W. Warren

    48 Azotemia and Urinary Abnormalities
    David B. Mount

    49 Fluid and Electrolyte Disturbances
    David B. Mount

    50 Hypercalcemia and Hypocalcemia
    Sundeep Khosla

    51 Acidosis and Alkalosis
    Thomas D. DuBose, Jr.
     
    Section 8: Alterations in the Skin
     
    52 Approach to the Patient with a Skin Disorder
    Kim B. Yancey, Thomas J. Lawley

    53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
    Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley

    54 Skin Manifestations of Internal Disease
    Jean L. Bolognia, Irwin M. Braverman

    55 Immunologically Mediated Skin Diseases
    Kim B. Yancey, Thomas J. Lawley

    56 Cutaneous Drug Reactions
    Robert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai

    57 Photosensitivity and Other Reactions to Light
    Alexander G. Marneros, David R. Bickers
     
    Section 9: Hematologic Alterations
     
    58 Interpreting Peripheral Blood Smears 
    Dan L. Longo

    59 Anemia and Polycythemia
    John W. Adamson, Dan L. Longo

    60 Disorders of Granulocytes and Monocytes
    Steven M. Holland, John I. Gallin

    61 Bleeding and Thrombosis
    Barbara A. Konkle

    62 Enlargement of Lymph Nodes and Spleen
    Dan L. Longo
     
    Part 3: Pharmacology
     
    63 Principles of Clinical Pharmacology
    Dan M. Roden

    64 Pharmacogenomics
    Dan M. Roden
     
    Part 4: Oncology and Hematology
     
    Section 1: Neoplastic Disorders
     
    65 Approach to the Patient with Cancer
    Dan L. Longo

    66 Prevention and Early Detection of "Cancer
    Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer

    67 Cancer Genetics
    Fred Bunz, Bert Vogelstein

    68 Cancer Cell Biology
    Jeffrey W. Clark, Dan L. Longo

    69 Principles of Cancer Treatment
    Edward A. Sausville, Dan L. Longo

    70 Infections in Patients with Cancer
    Robert W. Finberg

    71 Oncologic Emergencies
    Rasim Gucalp, Janice P. Dutcher

    72 Cancer of the Skin
    Brendan D. Curti, Sancy Leachman, Walter J. Urba 

    73 Head and Neck Cancer
    Everett E. Vokes

    74 Neoplasms of the Lung
    Leora Horn, Christine M. Lovly

    75 Breast Cancer
    Daniel F. Hayes, Marc E. Lippman

    76 Upper Gastrointestinal Tract Cancers
    Robert J. Mayer

    77 Lower Gastrointestinal Cancers
    Robert J. Mayer

    78 Tumors of the Liver and Biliary Tree
    Josep M. Llovet

    79 Pancreatic Cancer
    Daniel D. Von Hoff

    80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
    Robert T. Jensen

    81 Renal Cell Carcinoma
    Robert J. Motzer

    82 Cancer of the Bladder and Urinary Tract
    Noah M. Hahn

    83 Benign and Malignant Diseases of the Prostate
    Howard I. Scher, James A. Eastham

    84 Testicular Cancer
    David J. Vaughn

    85 Gynecologic Malignancies
    David Spriggs

    86 Primary and Metastatic Tumors of the Nervous System
    Lisa M. DeAngelis, Patrick Y. Wen

    87 Soft Tissue and Bone Sarcomas and Bone Metastases
    Shreyaskumar R. Patel

    88 Carcinoma of Unknown Primary
    Gauri R. Varadhachary, James L. Abbruzzese

    89 Paraneoplastic Syndromes: Endocrinologic/Hematologic
    J. Larry Jameson, Dan L. Longo

    90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
    Josep Dalmau, Myrna R. Rosenfeld

    91 Late Consequences of Cancer and Its Treatment
    Carl E. Freter, Dan L. Longo
     
    Section 2: Hematopoietic Disorders
     
    92 Hematopoietic Stem Cells
    David T. Scadden, Dan L. Longo

    93 Iron Deficiency and Other Hypoproliferative Anemias
    John W. Adamson

    94 Disorders of Hemoglobin
    Edward J. Benz, Jr.

    95 Megaloblastic Anemias
    A. Victor Hoffbrand

    96 Hemolytic Anemias 
    Lucio Luzzatto

    97 Anemia Due to Acute Blood Loss
    Dan L. Longo

    98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
    Neal S. Young

    99 Polycythemia Vera and Other Myeloproliferative Neoplasms
    Jerry L. Spivak

    100 Acute Myeloid Leukemia
    William Blum, Clara D. Bloomfield

    101 Chronic Myeloid Leukemia
    Hagop Kantarjian, Jorge Cortes

    102 Acute Lymphoid Leukemia
    Dieter Hoelzer 

    103 Chronic Lymphocytic Leukemia
    Jennifer A. Woyach, John C. Byrd

    104 Non-Hodgkin's Lymphoma
    Caron A. Jacobson, Dan L. Longo

    105 Hodgkin's Lymphoma 
    Caron A. Jacobson, Dan L. Longo

    106 Less Common Hematologic Malignancies
    Ayalew Tefferi, Dan L. Longo

    107 Plasma Cell Disorders
    Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson

    108 Amyloidosis
    John L. Berk, Vaishali Sanchorawala 

    109 Transfusion Biology and Therapy
    Jeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson

    110 Hematopoietic Cell Transplantation
    Frederick R. Appelbaum
     
    Section 3: Disorders of Hemostasis
     
    111 Disorders of Platelets and Vessel Wall
    Barbara A. Konkle

    112 Coagulation Disorders
    Valder R. Arruda, Katherine A. High

    113 Arterial and Venous Thrombosis
    Jane E. Freedman, Joseph Loscalzo

    114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
    Jeffrey I. Weitz
     
    Part 5: Infectious Diseases
     
    Section 1: Basic Considerations in Infectious Diseases
     
    115 Approach to the Patient with an Infectious Disease
    Neeraj K. Surana, Dennis L. Kasper

    116 Molecular Mechanisms of Microbial Pathogenesis
    Gerald B. Pier

    117 Approach to the Acutely Ill Infected Febrile Patient
    Tamar F. Barlam, Dennis L. Kasper

    118 Immunization Principles and Vaccine Use
    Nancy Messonnier, Anne Schuchat, Lisa A. Jackson

    119 Health Recommendations for International Travel
    Jay S. Keystone, Phyllis E. Kozarsky

    120 Climate Change and Infectious Disease
    Aaron S. Bernstein
     
    Section 2: Clinical Syndromes: Community-Acquired Infections
     
    121 Pneumonia
    Lionel A. Mandell, Richard G. Wunderink

    122 Lung Abscess
    Rebecca M. Baron, Miriam Baron Barshak

    123 Infective Endocarditis
    Adolf W. Karchmer

    124 Infections of the Skin, Muscles, and Soft Tissues
    Dennis L. Stevens

    125 Infectious Arthritis
    Lawrence C. Madoff

    126 Osteomyelitis
    Werner Zimmerli

    127 Intraabdominal Infections and Abscesses
    Miriam Baron Barshak, Dennis L. Kasper

    128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
    Richelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque

    129 Clostridium difficile Infection, Including Pseudomembranous Colitis
    Dale N. Gerding, Stuart Johnson

    130 Urinary Tract Infections, Pyelonephritis, and Prostatitis
    Kalpana Gupta, Barbara W. Trautner

    131 Sexually Transmitted Infections: Overview and Clinical Approach
    Jeanne M. Marrazzo, King K. Holmes

    132 Encephalitis
    Karen L. Roos, Kenneth L. Tyler

    133 Acute Meningitis
    Karen L. Roos, Kenneth L. Tyler

    134 Chronic and Recurrent Meningitis
    Walter J. Koroshetz, Michael R. Wilson, Avindra Nath

    135 Brain Abscess and Empyema
    Karen L. Roos, Kenneth L. Tyler

    136 Infectious Complications of Bites
    Sandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff
     
    Section 3: Clinical Syndromes: Health Care-Associated Infections
     
    137 Infections Acquired in Health Care Facilities
    Robert A. Weinstein

    138 Infections in Transplant Recipients
    Robert W. Finberg, Joyce D. Fingeroth
     
    Section 4: Therapy for Bacterial Diseases
     
    139 Treatment and Prophylaxis of Bacterial Infections
    David C. Hooper, Erica S. Shenoy, Christy A. Varughese

    140 Bacterial Resistance to Antimicrobial Agents
    David C. Hooper
     
    Section 5: Diseases Caused by Gram-Positive Bacteria
     
    141 Pneumococcal Infections
    David Goldblatt, Katherine L. O'Brien

    142 Staphylococcal Infections
    Franklin D. Lowy

    143 Streptococcal Infections
    Michael R. Wessels

    144 Enterococcal Infections
    Cesar A. Arias, Barbara E. Murray

    145 Diphtheria and Other Corynebacterial Infections
    William R. Bishai, John R. Murphy

    146 Listeria monocytogenes Infections
    Elizabeth L. Hohmann, Daniel A. Portnoy

    147 Tetanus
    C. Louise Thwaites, Lam Minh Yen

    148 Botulism
    Agam K. Rao, Susan Maslanka

    149 Gas Gangrene and Other Clostridial Infections
    Amy E. Bryant, Dennis L. Stevens
     
    Section 6: Diseases Caused by Gram-Negative Bacteria
     
    150 Meningococcal Infections
    Andrew J. Pollard 

    151 Gonococcal Infections
    Sanjay Ram, Peter A. Rice

    152 Haemophilus and Moraxella Infections
    Timothy F. Murphy

    153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
    Tamar F. Barlam, Dennis L. Kasper

    154 Legionella Infections
    Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin

    155 Pertussis and Other Bordetella Infections
    Karina A. Top, Scott A. Halperin

    156 Diseases Caused by Gram-Negative Enteric Bacilli
    Thomas A. Russo, James R. Johnson

    157 Acinetobacter Infections
    Rossana Rosa, L. Silvia Munoz-Price

    158 Helicobacter pylori Infections
    John C. Atherton, Martin J. Blaser

    159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
    Reuben Ramphal

    160 Salmonellosis
    David A. Pegues, Samuel I. Miller

    161 Shigellosis
    Philippe J. Sansonetti, Jean Bergounioux

    162 Infections Due to Campylobacter and Related Organisms
    Beth D. Kirkpatrick, Martin J. Blaser

    163 Cholera and Other Vibrioses
    Matthew K. Waldor, Edward T. Ryan 

    164 Brucellosis
    Nicholas J. Beeching

    165 Tularemia
    Jeannine M. Petersen, Paul S. Mead

    166 Plague and Other Yersinia Infections
    Michael B. Prentice

    167 Bartonella Infections, Including Cat-Scratch Disease
    Michael Giladi, Moshe Ephros

    168 Donovanosis
    Nigel O'Farrell
     
    Section 7: Miscellaneous Bacterial Infections
     
    169 Nocardiosis
    Gregory A. Filice

    170 Actinomycosis 
    Thomas A. Russo

    171 Whipple's Disease
    Thomas A. Russo

    172 Infections Due to Mixed Anaerobic Organisms
    Neeraj K. Surana, Dennis L. Kasper
     
    Section 8: Mycobacterial Diseases
     
    173 Tuberculosis
    Mario C. Raviglione

    174 Leprosy
    Robert H. Gelber

    175 Nontuberculous Mycobacterial Infections
    Steven M. Holland

    176 Antimycobacterial Agents
    Divya Reddy, Max R. O'Donnell
     
    Section 9: Spirochetal Diseases
     
    177 Syphilis
    Sheila A. Lukehart

    178 Endemic Treponematoses
    Sheila A. Lukehart

    179 Leptospirosis
    Jiri F. P. Wagenaar, Marga G. A. Goris

    180 Relapsing Fever
    Alan G. Barbour

    181 Lyme Borreliosis
    Allen C. Steere
     
    Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
     
    182 Rickettsial Diseases
    David H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas J. Marrie

    183 Infections Due to Mycoplasmas
    R. Doug Hardy

    184 Chlamydial Infections
    Charlotte A. Gaydos, Thomas C. Quinn
     
    Section 11: Viral Diseases: General Considerations
     
    185 Medical Virology
    Fred Wang, Elliott Kieff

    186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
    Lindsey R. Baden
     
    Section 12: Infections Due to DNA Viruses
     
    187 Herpes Simplex Virus Infections
    Lawrence Corey

    188 Varicella-Zoster Virus Infections
    Richard J. Whitley

    189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
    Jeffrey I. Cohen

    190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
    Camille Nelson Kotton, Martin S. Hirsch

    191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections
    Fred Wang

    192 Parvovirus Infections
    Kevin E. Brown

    193 Human Papillomavirus Infections
    Darron R. Brown, Aaron Ermel
     
    Section 13: Infections Due to DNA and RNA Respiratory Viruses
     
    194 Common Viral Respiratory Infections 
    James E. Crowe, Jr.

    195 Influenza
    Peter F. Wright
     
    Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
     
    196 The Human Retroviruses
    Dan L. Longo, Anthony S. Fauci

    197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
    Anthony S. Fauci, Gregory K. Folkers, H. Clifford Lane
     
    Section 15: Infections Due to RNA Viruses
     
    198 Viral Gastroenteritis
    Umesh D. Parashar, Roger I. Glass

    199 Enterovirus, Parechovirus, and Reovirus Infections
    Jeffrey I. Cohen

    200 Measles (Rubeola)
    Kaitlin Rainwater-Lovett, William J. Moss

    201 Rubella (German Measles)
    Laura A. Zimmerman, Susan E. Reef

    202 Mumps
    Steven A. Rubin

    203 Rabies and Other Rhabdovirus Infections
    Alan C. Jackson

    204 Arthropod-Borne and Rodent-Borne Virus Infections
    Jens H. Kuhn, Remi N. Charrel

    205 Ebolavirus and Marburgvirus Infections
    Jens H. Kuhn
     
    Section 16: Fungal Infections
     
    206 Diagnosis and Treatment of Fungal Infections
    John E. Edwards, Jr. 

    207 Histoplasmosis
    Chadi A. Hage, L. Joseph Wheat

    208 Coccidioidomycosis
    Neil M. Ampel

    209 Blastomycosis
    S. Travis King, Rathel L. Nolan, III 

    210 Cryptococcosis
    Arturo Casadevall

    211 Candidiasis
    John E. Edwards, Jr.

    212 Aspergillosis
    David W. Denning

    213 Mucormycosis
    Brad Spellberg, Ashraf S. Ibrahim

    214 Superficial Mycoses and Less Common Systemic Mycoses
    Carol A. Kauffman

    215 Pneumocystis Infections
    Alison Morris, Henry Masur
     
    Section 17: Protozoal and Helminthic Infections: General Considerations
     
    216 Introduction to Parasitic Infections 
    Sharon L. Reed, Charles E. Davis

    217 Agents Used to Treat Parasitic Infections
    Thomas A. Moore
     
    Section 18: Protozoal Infections
     
    218 Amebiasis and Infection with Free-Living Amebae
    Rosa M. Andrade, Sharon L. Reed

    219 Malaria
    Nicholas J. White, Elizabeth A. Ashley

    220 Babesiosis
    Edouard Vannier, Peter J. Krause

    221 Leishmaniasis
    Shyam Sundar

    222 Chagas Disease and African Trypanosomiasis
    Francois Chappuis, Yves Jackson

    223 Toxoplasma Infections
    Kami Kim

    224 Protozoal Intestinal Infections and Trichomoniasis
    Peter F. Weller
     
    Section 19: Helminthic Infections
     
    225 Introduction to Helminthic Infections
    Peter F. Weller

    226 Trichinellosis and Other Tissue Nematode Infections
    Peter F. Weller

    227 Intestinal Nematode Infections
    Peter F. Weller, Thomas B. Nutman

    228 Filarial and Related Infections
    Thomas B. Nutman, Peter F. Weller

    229 Schistosomiasis and Other Trematode Infections
    Birgitte Jyding Vennervald

    230 Cestode Infections
    A. Clinton White, Jr., Peter F. Weller
     
    Part 6: Disorders of the Cardiovascular System
     
    Section 1: Introduction to Cardiovascular Disorders
     
    231 Approach to the Patient with Possible Cardiovascular Disease
    Joseph Loscalzo

    232 Basic Biology of the Cardiovascular System
    Joseph Loscalzo, Peter Libby, Calum A. MacRae

    233 Epidemiology of Cardiovascular Disease
    Thomas A. Gaziano, J. Michael Gaziano
     
    Section 2: Diagnosis of Cardiovascular Disorders
     
    234 Physical Examination of the Cardiovascular System
    Patrick T. O'Gara, Joseph Loscalzo

    235 Electrocardiography
    Ary L. Goldberger

    236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
    Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 

    237 Diagnostic Cardiac Catheterization and Coronary Angiography
    Jane A. Leopold, David P. Faxon
     
    Section 3: Disorders of Rhythm
     
    238 Principles of Electrophysiology
    David D. Spragg, Gordon F. Tomaselli

    239 The Bradyarrhythmias: Disorders of the Sinoatrial Node
    David D. Spragg, Gordon F. Tomaselli

    240 The Bradyarrhythmias: Disorders of the Atrioventricular Node
    David D. Spragg, Gordon F. Tomaselli

    241 Approach to Supraventricular Tachyarrhythmias
    Gregory F. Michaud, William G. Stevenson

    242 Physiologic and Non-physiologic Sinus Tachycardia 
    Gregory F. Michaud, William G. Stevenson

    243 Focal Atrial Tachycardia 
    Gregory F. Michaud, William G. Stevenson

    244 Paroxysmal Supraventricular Tachycardias
    Gregory F. Michaud, William G. Stevenson

    245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias
    Gregory F. Michaud, William G. Stevenson

    246 Atrial Fibrillation
    Gregory F. Michaud, William G. Stevenson

    247 Approach to Ventricular Arrhythmias 
    Roy M. John, William G. Stevenson

    248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm 
    Roy M. John, William G. Stevenson

    249 Sustained Ventricular Tachycardia 
    William G. Stevenson, Roy M. John

    250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
    William G. Stevenson, Roy M. John

    251 Electrical Storm and Incessant VT
    William G. Stevenson, Roy M. John
     
    Section 4: Disorders of the Heart
     
    252 Heart Failure: Pathophysiology and Diagnosis
    Douglas L. Mann, Murali Chakinala

    253 Heart Failure: Management
    Mandeep R. Mehra 

    254 Cardiomyopathy and Myocarditis
    Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo

    255 Cardiac Transplantation and Prolonged Assisted Circulation 
    Mandeep R. Mehra

    256 Aortic Valve "Disease
    Patrick T. O'Gara, Joseph Loscalzo

    257 Aortic Regurgitation 
    Patrick T. O'Gara, Joseph Loscalzo

    258 Mitral Stenosis
    Patrick T. O'Gara, Joseph Loscalzo

    259 Mitral Regurgitation
    Patrick T. O'Gara, Joseph Loscalzo

    260 Mitral Valve Prolapse
    Patrick T. O'Gara, Joseph Loscalzo

    261 Tricuspid Valve Disease
    Patrick T. O'Gara, Joseph Loscalzo

    262 Pulmonic Valve Disease
    Patrick T. O'Gara, Joseph Loscalzo

    263 Multiple and Mixed Valvular Heart Disease
    Patrick T. O'Gara, Joseph Loscalzo

    264 Congenital Heart Disease in the Adult
    Anne Marie Valente, Michael J. Landzberg

    265 Pericardial Disease
    Eugene Braunwald

    266 Atrial Myxoma and Other Cardiac Tumors
    Eric H. Awtry
     
    Section 5: Coronary and Peripheral Vascular Disease
     
    267 Ischemic Heart Disease
    Elliott Antman, Joseph Loscalzo

    268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
    Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald

    269 ST-Segment Elevation Myocardial Infarction
    Elliott M. Antman, Joseph Loscalzo

    270 Percutaneous Coronary Interventions and Other Interventional Procedures
    David P. Faxon, Deepak L. Bhatt

    271 Hypertensive Vascular Disease
    Theodore A. Kotchen

    272 Renovascular Disease
    Stephen C. Textor

    273 Deep Venous Thrombosis and Pulmonary Thromboembolism
    Samuel Z. Goldhaber

    274 Diseases of the Aorta
    Mark A. Creager, Joseph Loscalzo

    275 Arterial Diseases of the Extremities
    Mark A. Creager, Joseph Loscalzo

    276 Chronic Venous Disease and Lymphedema 
    Mark A. Creager, Joseph Loscalzo

    277 Pulmonary Hypertension
    Aaron B. Waxman, Joseph Loscalzo
     
    Part 7: Disorders of the Respiratory System
     
    Section 1: Diagnosis of Respiratory Disorders
     
    278 Approach to the Patient with Disease of the Respiratory System
    Patricia A. Kritek, Bruce D. Levy

    279 Disturbances of Respiratory Function
    Edward T. Naureckas, Julian Solway 

    280 Diagnostic Procedures in Respiratory Disease
    Anne L. Fuhlbrigge, Augustine M.K. Choi 
     
    Section 2: Diseases of the Respiratory System
     
    281 Asthma
    Peter J. Barnes

    282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
    Praveen Akuthota, Michael E. Wechsler

    283 Occupational and Environmental Lung Disease
    John R. Balmes

    284 Bronchiectasis
    Rebecca M. Baron, Miriam Baron Barshak

    285 Cystic Fibrosis
    Eric J. Sorscher

    286 Chronic Obstructive Pulmonary Disease
    Edwin K. Silverman, James D. Crapo, Barry Make

    287 Interstitial Lung Disease
    Gary M. Hunninghake, Ivan O. Rosas

    288 Disorders of the Pleura
    Richard W. Light

    289 Disorders of the Mediastinum
    Richard W. Light

    290 Disorders of Ventilation 
    John F. McConville, Julian Solway, Babak Mokhlesi 

    291 Sleep Apnea
    Andrew Wellman, Susan Redline

    292 Lung Transplantation
    Elbert P. Trulock, III
     
    Part 8: Critical Care Medicine
     
    Section 1: Respiratory Critical Care
     
    293 Approach to the Patient with Critical Illness
    John P. Kress, Jesse B. Hall

    294 Acute Respiratory Distress Syndrome
    Rebecca M. Baron, Bruce D. Levy

    295 Mechanical Ventilatory Support
    Bartolome R. Celli
     
    Section 2: Shock and Cardiac Arrest
     
    296 Approach to the Patient with Shock
    Anthony F. Massaro

    297 Sepsis and Septic Shock
    Christopher W. Seymour, Derek C. Angus

    298 Cardiogenic Shock and Pulmonary Edema
    David H. Ingbar, Holger Thiele

    299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death 
    Christine M. Albert, William G. Stevenson 
     
    Section 3: Neurologic Critical Care
     
    300 Coma
    S. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser 

    301 Severe Acute Encephalopathies and Critical Care Weakness
    J. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress

    302 Subarachnoid Hemorrhage
    J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress
     
    Part 9: Disorders of the Kidney and Urinary Tract
     
    303 Cellular and Molecular Biology of the Kidney
    Alfred L. George, Jr., Eric G. Neilson

    304 Acute Kidney Injury
    Sushrut S. Waikar, Joseph V. Bonventre

    305 Chronic Kidney Disease 
    Joanne M. Bargman, Karl L. Skorecki

    306 Dialysis in the Treatment of Renal Failure
    Kathleen D. Liu, Glenn M. Chertow

    307 Transplantation in the Treatment of Renal Failure
    Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker 

    308 Glomerular Diseases
    Julia B. Lewis, Eric G. Neilson

    309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
    Jing Zhou, Martin R.  Pollak

    310 Tubulointerstitial Diseases of the Kidney
    Laurence H. Beck, Jr., David J. Salant

    311 Vascular Injury to the Kidney
    Ronald S. Go, Nelson Leung

    312 Nephrolithiasis
    Gary C. Curhan

    313 Urinary Tract Obstruction
    Julian L. Seifter
     
    Part 10: Disorders of the Gastrointestinal System
     
    Section 1: Disorders of the Alimentary Tract
     
    314 Approach to the Patient with Gastrointestinal Disease
    William L. Hasler, Chung Owyang

    315 Gastrointestinal Endoscopy
    Louis Michel Wong Kee Song, Mark Topazian

    316 Diseases of the Esophagus
    Peter J. Kahrilas, Ikuo Hirano

    317 Peptic Ulcer Disease and Related Disorders
    John Del Valle

    318 Disorders of Absorption
    Henry J. Binder

    319 Inflammatory Bowel Disease
    Sonia Friedman, Richard S. Blumberg

    320 Irritable Bowel Syndrome
    Chung Owyang

    321 Diverticular Disease and Common Anorectal Disorders
    Rizwan Ahmed, Susan L. Gearhart

    322 Mesenteric Vascular Insufficiency
    Satinderjit Locham, Mahmoud Malas

    323 Acute Intestinal Obstruction
    Danny O. Jacobs

    324 Acute Appendicitis and Peritonitis
    Danny O. Jacobs
     
    Section 2: Nutrition 
     
    325 Nutrient Requirements and Dietary Assessment
    Johanna Dwyer

    326 Vitamin and Trace Mineral Deficiency and Excess
    Paolo M. Suter, Robert M. Russell

    327 Malnutrition and Nutritional Assessment 
    Gordon L. Jensen

    328 Enteral and Parenteral Nutrition
    L. John Hoffer, Bruce R. Bistrian, David F. Driscoll
     
    Section 3: Liver and Biliary Tract Disease
     
    329 Approach to the Patient with Liver Disease
    Marc G. Ghany, Jay H. Hoofnagle 

    330 Evaluation of Liver Function
    Daniel S. Pratt

    331 The Hyperbilirubinemias
    Allan W. Wolkoff

    332 Acute Viral Hepatitis
    Jules L. Dienstag

    333 Toxic and Drug-Induced Hepatitis
    William M. Lee, Jules L. Dienstag

    334 Chronic Hepatitis
    Jules L. Dienstag

    335 Alcoholic Liver Disease
    Mark E. Mailliard, Michael F. Sorrell

    336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis
    Manal F. Abdelmalek, Anna Mae Diehl

    337 Cirrhosis and Its Complications
    Bruce R. Bacon

    338 Liver Transplantation
    Raymond T. Chung, Jules L. Dienstag

    339 Diseases of the Gallbladder and Bile Ducts
    Norton J. Greenberger, Gustav Paumgartner
     
    Section 4: Disorders of the Pancreas
     
    340 Approach to the Patient with Pancreatic Disease
    Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks

    341 Acute and Chronic Pancreatitis
    Darwin L. Conwell, Peter A. Banks, Norton J. Greenberger
     
    Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
     
    Section 1: The Immune System in Health and Disease
     
    342 Introduction to the Immune System
    Barton F. Haynes, Kelly A. Soderberg, Anthony S. Fauci

    343 The Major Histocompatibility Complex
    Gerald T. Nepom

    344 Primary Immune Deficiency Diseases
    Alain Fischer
     
    Section 2: Disorders of Immune-Mediated Injury
     
    345 Urticaria, Angioedema, and Allergic Rhinitis 
    Katherine N. Cahill, Joshua A. Boyce

    346 Anaphylaxis
    David Hong, Joshua A. Boyce

    347 Mastocytosis
    Cem Akin, Joshua A. Boyce

    348 Autoimmunity and Autoimmune Diseases
    Betty Diamond, Peter E. Lipsky

    349 Systemic Lupus Erythematosus
    Bevra Hannahs Hahn

    350 Antiphospholipid Syndrome
    Haralampos M. Moutsopoulos

    351 Rheumatoid Arthritis
    Ankoor Shah, E. William St. Clair

    352 Acute Rheumatic Fever
    Jonathan R. Carapetis

    353 Systemic Sclerosis (Scleroderma) and Related Disorders
    John Varga

    354 Sjogren's Syndrome
    Haralampos M. Moutsopoulos

    355 The Spondyloarthritides
    Joel D. Taurog

    356 The Vasculitis Syndromes
    Carol A. Langford, Anthony S. Fauci

    357 Behcet's Syndrome
    Haralampos M. Moutsopoulos

    358 Inflammatory Myopathies
    Steven A. Greenberg, Anthony A. Amato

    359 Relapsing Polychondritis
    Carol A. Langford

    360 Sarcoidosis
    Robert P. Baughman, Elyse E. Lower

    361 IgG4-Related Disease
    John H. Stone

    362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases
    Daniel L. Kastner
     
    Section 3: Disorders of the Joints and Adjacent Tissues
     
    363 Approach to Articular and Musculoskeletal Disorders
    John J. Cush

    364 Osteoarthritis
    David T. Felson, Tuhina Neogi

    365 Gout and Other Crystal-Associated Arthropathies
    H. Ralph Schumacher, Lan X. Chen

    366 Fibromyalgia
    Leslie J. Crofford

    367 Arthritis Associated with Systemic Disease, and Other Arthritides
    Carol A. Langford, Brian F. Mandell 

    368 Periarticular Disorders of the Extremities
    Carol A. Langford
     
    Part 12: Endocrinology and Metabolism
     
    Section 1: Endocrinology
     
    369 Approach to the Patient with Endocrine Disorders
    J. Larry Jameson

    370 Mechanisms of Hormone Action
    J. Larry Jameson

    371 Physiology of Anterior Pituitary Hormones
    Shlomo Melmed, J. Larry Jameson

    372 Hypopituitarism
    Shlomo Melmed, J. Larry Jameson

    373 Pituitary Tumor Syndromes
    Shlomo Melmed, J. Larry Jameson

    374 Disorders of the Neurohypophysis
    Gary L. Robertson

    375 Thyroid Gland Physiology and Testing
    J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman

    376 Hypothyroidism
    J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman

    377 Hyperthyroidism
    J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman

    378 Thyroid Nodular Disease and Thyroid Cancer
    J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman

    379 Disorders of the Adrenal Cortex
    Wiebke Arlt

    380 Pheochromocytoma
    Hartmut P. H. Neumann

    381 Multiple Endocrine Neoplasia
    R. V. Thakker

    382 Autoimmune Polyendocrine Syndromes
    Peter A. Gottlieb, Aaron W. Michels
     
    Section 2: Sex- and Gender-Based Medicine
     
    383 Disorders of Sex Development
    John C. Achermann, J. Larry Jameson

    384 Disorders of the Testes and Male Reproductive System
    Shalender Bhasin, J. Larry Jameson

    385 Disorders of the Female Reproductive System
    Janet E. Hall

    386 Menstrual Disorders and Pelvic Pain
    Janet E. Hall

    387 Hirsutism
    David A. Ehrmann

    388 Menopause and Postmenopausal Hormone Therapy
    JoAnn E. Manson, Shari S. Bassuk

    389 Infertility and Contraception
    Janet E. Hall

    390 Sexual Dysfunction
    Kevin T. McVary

    391 Women's Health
    Andrea Dunaif

    392 Men's Health
    Shalender Bhasin, Shehzad Basaria

    393 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health
    Baligh R. Yehia, Harvey J. Makadon
     
    Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome
     
    394 Pathobiology of Obesity 
    Jeffrey S. Flier, Eleftheria Maratos-Flier

    395 Evaluation and Management of Obesity
    Robert F. Kushner

    396 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
    Alvin C. Powers, Kevin D. Niswender, Carmella Evans-Molina

    397 Diabetes Mellitus: Management and Therapies
    Alvin C. Powers, Kevin D. Niswender, Michael R. Rickels

    398 Diabetes Mellitus: Complications
    Alvin C. Powers, John M. Stafford, Michael R. Rickels

    399 Hypoglycemia
    Philip E. Cryer, Stephen N. Davis

    400 Disorders of Lipoprotein Metabolism
    Daniel J. Rader, Sekar Kathiresan

    401 The Metabolic Syndrome
    Robert H. Eckel
     
    Section 4: Disorders of Bone and Mineral Metabolism
     
    402 Bone and Mineral Metabolism in Health and Disease
    F. Richard Bringhurst, Marie B. Demay, Henry M. Kronenberg

    403 Disorders of the Parathyroid Gland and Calcium Homeostasis
    John T. Potts, Jr., Harald Juppner

    404 Osteoporosis
    Robert Lindsay, Felicia Cosman

    405 Paget's Disease and Other Dysplasias of Bone
    Murray J. Favus, Tamara J. Vokes
     
    Section 5: Disorders of Intermediary Metabolism
     
    406 Heritable Disorders of Connective Tissue
    Darwin J. Prockop, John F. Bateman

    407 Hemochromatosis
    Lawrie W. Powell

    408 Wilson's Disease
    George J. Brewer

    409 The Porphyrias
    Robert J. Desnick, Manisha Balwani

    410 Disorders of Purine and Pyrimidine Metabolism
    John N. Mecchella, Christopher M. Burns

    411 Lysosomal Storage Diseases
    Robert J. Hopkin, Gregory A. Grabowski

    412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
    Priya S. Kishnani, Yuan-Tsong Chen

    413 Inherited Disorders of Amino Acid Metabolism in Adults
    Nicola Longo

    414 Inherited Defects of Membrane Transport
    Nicola Longo
     
    Part 13: Neurologic Disorders
     
    Section 1: Diagnosis of Neurologic Disorders
     
    415 Approach to the Patient with Neurologic Disease
    Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser

    416 Neuroimaging in Neurologic Disorders
    William P. Dillon

    417 Pathobiology of Neurologic Diseases
    Stephen L. Hauser, Arnold R. Kriegstein, Stanley B. Prusiner
     
    Section 2: Diseases of the Central Nervous System
     
    418 Seizures and Epilepsy
    Daniel H. Lowenstein

    419 Cerebrovascular Diseases
    Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III

    420 Ischemic Stroke 
    Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III

    421 Intracranial Hemorrhage 
    Wade S. Smith, J. Claude Hemphill, III, S. Claiborne Johnston

    422 Migraine and Other Primary Headache Disorders
    Peter J. Goadsby

    423 Alzheimer's Disease 
    William W. Seeley, Bruce L. Miller

    424 Frontotemporal Dementia
    William W. Seeley, Bruce L. Miller

    425 Vascular Dementia
    Joel H. Kramer, William W. Seeley, Bruce L. Miller

    426 Dementia with Lewy Bodies 
    William W. Seeley, Caroline M. Tanner, Bruce L. Miller

    427 Parkinson's Disease 
    C. Warren Olanow, Christine Klein, Anthony H. V. Schapira

    428 Tremor, Chorea, and Other Movement Disorders
    C. Warren Olanow, Christine Klein, Jose A. Obeso

    429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
    Robert H. Brown, Jr.

    430 Prion Diseases
    Stanley B. Prusiner, Bruce L. Miller

    431 Ataxic Disorders
    Roger N. Rosenberg

    432 Disorders of the Autonomic Nervous System
    Christopher H. Gibbons, John W. Engstrom

    433 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders
    M. Flint Beal, Stephen L. Hauser

    434 Diseases of the Spinal Cord
    Stephen L. Hauser

    435 Concussion and Other Traumatic Brain Injuries
    Geoffrey T. Manley, Stephen L. Hauser, Michael McCrea

    436 Multiple Sclerosis 
    Bruce A. C. Cree, Stephen L. Hauser

    437 Neuromyelitis Optica
    Bruce A. C. Cree, Stephen L. Hauser
     
    Section 3: Nerve and Muscle Disorders
     
    438 Peripheral Neuropathy
    Anthony A. Amato, Richard J. Barohn

    439 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies
    Stephen L. Hauser, Anthony A. Amato

    440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
    Anthony A. Amato

    441 Muscular Dystrophies and Other Muscle Diseases
    Anthony A. Amato, Robert H. Brown, Jr.
     
    Section 4: Chronic Fatigue Syndrome
     
    442 Chronic Fatigue Syndrome
    Gijs Bleijenberg, Jos W. M. van der Meer
     
    Section 5: Psychiatric and Addiction Disorders
     
    443 Biology of Psychiatric Disorders
    Robert O. Messing, Eric J. Nestler, Matthew W. State

    444 Psychiatric Disorders
    Victor I. Reus

    445 Alcohol and Alcohol Use Disorders
    Marc A. Schuckit

    446 Opioid-Related Disorders
    Thomas R. Kosten, Colin N. Haile

    447 Cocaine and Other Commonly Used Drugs
    Karran A. Phillips, Antonello Bonci

    448 Nicotine Addiction
    David M. Burns
     
    Part 14: Poisoning, Drug Overdose, and Envenomation
     
    449 Heavy Metal Poisoning
    Howard Hu

    450 Poisoning and Drug Overdose
    Mark B. Mycyk

    451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures
    Charles Lei, Kirsten B. Hornbeak, Paul S. Auerbach, Robert L. Norris

    452 Ectoparasite Infestations and Arthropod Injuries
    Richard J. Pollack, Scott A. Norton
     
    Part 15: Disorders Associated with Environmental Exposures
     
    453 Altitude Illness
    Buddha Basnyat, Geoffrey Tabin

    454 Hypothermia and Peripheral Cold Injuries
    Daniel F. Danzl

    455 Heat-Related Illnesses
    Daniel F. Danzl
     
    Part 16: Genes, the Environment, and Disease
     
    456 Principles of Human Genetics
    J. Larry Jameson, Peter Kopp

    457 The Practice of Genetics in Clinical Medicine
    Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt

    458 Gene and Cell Based Therapy in Clinical Medicine
    Katherine A. High, Malcolm K. Brenner

    459 The Human Microbiome
    Neeraj K. Surana, Dennis L. Kasper
     
    Part 17: Global Medicine
     
    460 Global Issues in Medicine
    Joseph J. Rhatigan, Paul Farmer

    461 Worldwide Changes in Patterns of Infectious Disease
    George W. Rutherford, Jaime Sepulveda

    462 Primary Care and Global Health 
    Tim Evans, Kumanan Rasanathan
     
    Part 18: Aging
     
    463 The Biology of Aging
    Rafael de Cabo, David G. Le Couteur

    464 Clinical Problems Associated with the Aging Process
    Joseph G. Ouslander, Bernardo Reyes
     
    Part 19: Consultative Medicine
     
    465 Approach to Medical Consultation
    Jack Ende, Jeffrey Berns

    466 Medical Disorders During Pregnancy
    Robert L. Barbieri, John T. Repke

    467 Medical Evaluation of the Surgical Patient
    Prashant Vaishnava, Kim A. Eagle
     
    Part 20: Frontiers
     
    468 Behavioral Economics and Health 
    Kevin G. Volpp, George Loewenstein, David A. Asch

    469 Complementary, Alternative, and Integrative Health Approaches
    Josephine P. Briggs

    470 Telomere Disease
    Rodrigo T. Calado, Neal S. Young

    471 The Role of Epigenetics in Disease and Treatment
    Brian C. Capell, Shelley L. Berger

    472 Mitochondrial DNA and Heritable Traits and Diseases
    Karl L. Skorecki, Bruce H. Cohen

    473 Applications of Stem Cell Biology in Clinical Medicine
    John A. Kessler

    474 Microbial Genomics and Infectious Disease
    Roby P. Bhattacharyya, Yonatan H. Grad, Deborah T. Hung

    475 The Role of Circadian Biology in Health and Disease
    Jonathan Cedernaes, Kathryn Moynihan Ramsey, Joseph Bass

    476 Network Medicine: Systems Biology in Health and Disease
    Joseph Loscalzo

    477 Emerging Neurotherapeutic Technologies
    Jyoti Mishra, Karunesh Ganguly
     
    Online Chapters
    The following chapters are available online. They can be viewed at www.accessmedicine.com.
     
    Part 21: Video Collection
     
    V1 Video Library of Gait Disorders
    Gail Kang, Nicholas B. Galifianakis, Michael D. Geschwind

    V2 Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders
    Maria Luisa Gorno-Tempini, Jennifer Ogar, Joel Kramer, Bruce L. Miller, Gil Rabinovici, Maria Carmela Tartaglia

    V3 Video Library of Neuro-Ophthalmology
    Jonathan C. Horton

    V4 Examination of the Comatose Patient
    S. Andrew Josephson

    V5 Video Atlas of Gastrointestinal Endoscopic Lesions 
    Louis Michel Wong Kee Song, Mark Topazian

    V6 The Neurologic Screening Exam
    Daniel H. Lowenstein

    V7 Video Atlas of the Detailed Neurologic Examination
    Martin A. Samuels

    Part 22: Supplementary Topics
     
    S1 Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples
    David B. Mount, Thomas D. DuBose, Jr.

    S2 Microbial Bioterrorism
    H. Clifford Lane, Anthony S. Fauci

    S3 Chemical Terrorism
    Jonathan Newmark, James A. Romano, Jr. 

    S4 Radiation Terrorism
    Christine E. Hill-Kayser, Eli Glatstein, Zelig A. Tochner

    S5 Infections in War Veterans 
    Andrew W. Artenstein

    S6 Health Care for Military Veterans
    Stephen C. Hunt, Charles W. Hoge 

    S7 Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases
    Alain Fischer

    S8 Cardiac Trauma
    Eric H. Awtry

    S9 Technique of Lumbar Puncture
    Elizabeth Robbins, Stephen L. Hauser

    S10 Classification of the Spinocerebellar Ataxias
    Roger N. Rosenberg

    S11 Hyperbaric and Diving Medicine
    Michael H. Bennett, Simon J. Mitchell

    S12 The Clinical Laboratory in Modern Health Care
    Anthony A. Killeen

    S13 Laboratory Diagnosis of Infectious Diseases
    Alexander J. McAdam, Andrew B. Onderdonk

    S14 Laboratory Diagnosis of Parasitic Infections
    Sharon L. Reed, Charles E. Davis
     
    Part 23: Atlases
     
    A1 Atlas of Rashes Associated with Fever
    Kenneth M. Kaye, Elaine T. Kaye

    A2 Atlas of Oral Manifestations of Disease
    Samuel C. Durso, Janet A. Yellowitz

    A3 Atlas of Urinary Sediments and Renal Biopsies
    Agnes B. Fogo, Eric G. Neilson

    A4 Atlas of Skin Manifestations of Internal Disease
    Thomas J. Lawley, Benjamin K. Stoff, Calvin O. McCall

    A5 Atlas of Hematology
    Dan L. Longo

    A6 Atlas of Blood Smears of Malaria and Babesiosis
    Nicholas J. White, Joel G. Breman

    A7 Atlas of Electrocardiography
    Ary L. Goldberger

    A8 Atlas of Noninvasive Imaging
    Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 

    A9 Atlas of Cardiac Arrhythmias
    Ary L. Goldberger

    A10 Atlas of Atherosclerosis
    Peter Libby

    A11 Atlas of Percutaneous Revascularization
    Jane A. Leopold, Deepak L. Bhatt, David P. Faxon

    A12 Atlas of Chest Imaging
    Patricia A. Kritek, John J. Reilly, Jr.

    A13 Atlas of Liver Biopsies
    Jules L. Dienstag, Atul K. Bhan

    A14 Atlas of the Vasculitic Syndromes
    Carol A. Langford, Anthony S. Fauci

    A15 Atlas of Clinical Manifestations of Metabolic Diseases
    J. Larry Jameson

    A16 Atlas of Neuroimaging
    Andre D. Furtado, Luciano Villarinho, William P. Dillon 

    Index I-1