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Humana Lung Cancer Volume 2 Diagnostic And Therapeutic Methods And Reviews by Barbara Driscoll
This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer-both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher. Part I. IntroductionMolecular and Genetic Aspects of Lung CancerWilliam N. Rom and Kam-Meng Tchou-WongPart II. Detection of Altered Tumor Markers in Clinical Samples for Diagnosis and PrognosisA. Molecular Methods for Prognostic Detection of Altered Tumor Markers: Clinical ImplicationsMolecular Alterations in Lung Cancer: Impact on PrognosisTakashi Kijima, Gautam Maulik, and Ravi SalgiaCellular Predictive Factors of Drug Resistance in Non-Small Cell Lung CarcinomasManfred Volm, Reet Koomagi, and Werner RittgenClinical Implications of p53 Mutations in Lung CancerBarbara G. Campling and Wafik S. El-DeiryAn Epidemiologic and Clinicopathologic Overview of AIDS-Associated Pulmonary Kaposi's SarcomaDavid M. AboulafiaMyeloperoxidase Promoter Region Polymorphism and Lung Cancer RiskXifeng Wu, Matthew B. Schabath, and Margaret R. SpitzClinical Utility of Tumor Markers in the Management of Non-Small Cell Lung CancerDennis E. Niewoehner and Jeffrey B. RubinsB. Molecular Methods for Prognostic Detection of Altered Lung Tumor Markers in Clinical SamplesI. DNA-Based Analysis. Detection of Chromosomal Aberrations in Lung Tissue and Peripheral Blood Lymphocytes Using Interphase Fluorescence In Situ Hybridization (FISH)Randa A. El-Zein and Sherif Z. Abdel-RahmanIn Situ Analysis of Telomerase RNA Gene Expression as a Marker for Tumor ProgressionW. Nicol KeithA High-Throughput Methodology for Identifying Molecular Targets Overexpressed in Lung CancersTongtong Wang and Steven G. ReedExpression Profiling of Lung Cancer Based on Suppression Subtraction Hybridization (SSH)Simone Petersen and Iver PetersenComparative Genomic Hybridization of Human Lung CancerIver PetersenSensitive Assays for Detection of Lung Cancer: MolecularMarkers in Blood SamplesMarcia V. Fournier, Katherine J. Martin, Edgard Graner, and Arthur B. PardeeFluorescent Microsatellite Analysis in Bronchial Lavage as a Potential Diagnostic Tool for Lung CancerJohn K. Field and Triantafillos LiloglouSouthern Blotting of Genomic DNA from Lung and Its Tumors: Application to Analysis of Allele Loss on Chromosome 11p15.5Diana M. Pitterle and Gerold BeplerAssessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer RiskXifeng Wu, He Yu, Nimisha Makan, and Margaret R. SpitzII. PCR-Based Analyses. Comparative Multiplex PCR and Allele-Specific Expression Analysis in Human Lung Cancer: Tools to Facilitate Target IdentificationJim Heighway, Daniel Betticher, Teresa Knapp, and Paul HobanDetection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCTVeerle A. M. C. Somers and Frederick B. J. M. ThunnissenDetection of K-ras and p53 Mutations by 'Mutant-Enriched' PCR-RFLPMarcus SchuermannDetection of Small Cell Lung Cancer by RT-PCR for Neuropeptides, Neuropeptide Receptors, or a Splice Variant of the Neuron Restrictive Silencer FactorJudy M. Coulson, Samreen I. Ahmed, John P. Quinn, and Penella J. WollIII. Immunohistochemical AnalysesUtilization of Thyroid Transcription Factor-1 Immunostaining in the Diagnosis of Lung TumorsNelson G. OrdonezMolecular Biologic Substaining of Stage I NSCLC Through Immunohistochemistry Performed on Formalin-Fixed, Paraffin-Embedded TissueMary-Beth Moore Joshi, Thomas A. D'Amico, and David H. Harpole, JrA Sensitive Immunofluorescence Assay for Detection of p53 Protein in the SputumZumei Feng, Defa Tian, and Radoslav GoldmanSPR1: An Early Molecular Marker for Bronchial CarcinogenesisDerick Lau, Linlang Guo, Andrew