Description
Springer Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension 1st Editon 2020 Hardbound by Toshio Nakanishi, H. Scott Baldwin, Jeffrey R. Fineman, Hiroyuki Yamagishi
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus. PART I: Basic Science of Pulmonary Development and Pulmonary Arterial Disease.- 1 Perspective for Part I.- 2 The alveolar stem cell niche of the mammalian lung.- 3 Lung development and Notch signalling.- 4 Specialized smooth muscle cell progenitors in pulmonary hypertension.- 5 Diverse Pharmacology of Prostacyclin Mimetics: Implications for Pulmonary Hypertension.- 6 Endothelial-to-mesenchymal transition in pulmonary hypertension.- 7 Extracellular vesicles, MicroRNAs and Pulmonary Hypertension.- 8 Roles of Tbx4 in the lung mesenchyme for airway and vascular development.- 9 A lacZ reporter transgenic mouse line revealing the development of pulmonary artery.- 10 Roles of stem cell antigen-1 in the pulmonary endothelium.- 11 Morphological characterization of pulmonary microvascular disease in bronchopulmonary dysplasia caused by hyperoxia in newborn mice.- 12 Involvement of CXCR4 and stem cells in a rat model of pulmonary arterial hypertension.- 13 Ca2+ signal through inositol trisphosphate receptors for cardiovascular development and pathophysiology of pulmonary arterial hypertension.- PART II: Abnormal pulmonary circulation in the developing lung and heart.- 14 Perspective for Part II.- 15 Pathophysiology of Pulmonary Circulation in Congenital Heart Disease.- 16 Development of Novel Therapies for Pulmonary Hypertension by Clinical Application of Basic Research.- 17 Using Patient-Specific Induced Pluripotent Stem Cells to Understand and Treat Pulmonary Arterial Hypertension.- 18 Modeling pulmonary arterial hypertension using induced pluripotent stem cells.- 19 Dysfunction and restoration of endothelial cell communications in Pulmonary Arterial Hypertension: Therapeutic implications.- 20 Inflammatory Cytokines in the Pathogenesis of Pulmonary Arterial Hypertension.- 21 Genotypes and Phenotypes of Chinese Pediatric Patients with Idiopathic and Heritable Pulmonary Arterial Hypertension- Experiences from A Single Center.- 22 Fundamental Insight into Pulmonary Vascular Disease : Perspectives from Pediatric PAH in Japan.- 23 Risk stratification in paediatric pulmonary arterial hypertension.- 24 The Adaptive Right Ventricle in Eisenmenger Syndrome: Potential Therapeutic Targets for Pulmonary Hypertension.- 25 Impaired right coronary vasodilator function in pulmonary hypertensive rat assessed by in vivo synchrotron microangiography.- 26 Relationship between mutations in ENG and ALK1 gene and the affected organs in hereditary hemorrhagic telangiectasia.- 27 A genetic analysis for patients with pulmonary arterial hypertension.- 28 Evaluation and visualization of right ventricle using three dimensional echocardiography.- 29 Pulmonary hypertension associated with post-operative Tetralogy of Fallot.- 30 Microscopic Lung Airway Abnormality and Pulmonary Vascular Disease Associated with Congenital Systemic to Pulmonary Shunt.- 31 Respiratory syncytial virus infection in infants with heart and lung diseases.- PART III: Ductus arteriosus: bridge over troubled vessels.- 32 Perspective for Part III.- 33 The ductus arteriosus, a vascular outsider, in relation to the pulmonary circulation.- 34 Molecular, genetic, and pharmacological modulation of the ductus arteriosus: KATP channels as novel drug targets.- 35 New mediators in the biology of the ductus arteriosus: Lessons from the chicken embryo.- 36 Constriction of the Ductus Arteriosus with KATP Channel Inhibitors.- 37 New insights on how to treat patent ductus arteriosus.- 38 Antenatal Administration of Betamethasone Contributes to Intimal thickening of the Ductus Arteriosus.- 39 Prostaglandin E-EP4-mediated fibulin-1 up-regulation plays a role in intimal thickening of the ductus arteriosus.- 40 Transcriptional profiles in the chicken ductus arteriosus during hatching.- 41 Inhibition of Cyclooxygenase Contracts Chicken Ductus Arteriosus.- 42 Prostaglandin E2 r