Description
Humana Press Inc. Neural Mechanisms Of Anesthesia by Joseph E. Antognini
Leading investigators critically evaluate the latest information on how anesthetics work at the molecular, cellular, organ, and whole animal level. These distinguished experts review anesthetic effects on memory, consciousness, and movement and spell out in detail both the anatomic structures and physiological processes that are their likely targets, as well as the cellular and molecular mechanisms by which they operate. Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free ofundesirable side effects.
I. Introduction
The Development of Concepts of Mechanisms of Anesthesia
Donald Caton and Joseph F. Antognini
II. Anesthesia, Consciousness, and Memory
Mechanisms of Consciousness with Emphasis on the Cerebral Cortical Component
G. Bryan Young
Anesthesia Meets Memory: Tools for Critical Appraisal
Robert A. Veselis
III. Sleep, Coma, and Anesthesia-Similarities and Differences
Sleep and Anesthesia
John Keifer
Possible Relationships of Anesthetic Coma and Pathological Disorders of Consciousness
Nicholas D. Schiff and Fred Plum
IV. Neural Mechanisms
Cerebral Cortex-Anesthetic Action on the Electroencephalogram: Cellular and Synaptic Mechanisms and Clinical Monitoring
Heath Lukatch and Scott Greenwald
Cerebral Mechanisms of Analgesia and Anesthesia in Humans Elucidated by In Vivo Brain Imaging
Ferenc Gyulai and Leonard Firestone
Thalamus
Anthony Angel
The Hippocampus
M. Bruce MacIver
Anesthetic Effects on the Reticular Formation, Brainstem and Central Nervous System Arousal
Joseph F. Antognini and Earl Carstens
Anesthesia, the Spinal Cord and Motor Responses to Noxious Stimulation
Joseph F. Antognini and Earl Carstens
Spinal Cord-Dorsal Horn
J. G. Collins
Spinal Cord: Anesthetic Actions on Motor Neurons
Joan J. Kendig
Simple Genetic Models for Anesthetic Action
Philip G. Morgan and Margaret Sedensky
Genetic Dissection of Anesthetic Action
Gregg E. Homanics and Leonard L. Firestone
V. Cellular and Molecular Mechanisms
General Anesthetic Effects on GABAA Receptors
Robert A. Pearce
Nicotinic Acetylcholine Receptors and Anesthetics
Stuart A. Forman, Pamela Flood, and Douglas Raines
Actions of General Anesthetic on Voltage-Gated Ion Channels
Norbert Topf, Esperanza Recio-Pinto, Thomas J. J. Blanck, and Hugh C. Hemmings, Jr
Glutamate Receptors: Physiology and Anesthetic Pharmacology
Misha Perouansky and Joseph F. Antognini
General Anesthetic Effects on Glycine Receptors
Stephen Daniels
Presynaptic Actions of General Anesthetics
Misha Perouansky and Hugh C. Hemmings, Jr
The Meyer-Overton Relationship and Its Exceptions
Warren S. Sandberg and Keith W. Miller
Protein Models
Jonas S. Johansson and Roderic G. Eckenhoff
The Opioid Receptors
Gary J. Brenner, Jianren Mao, and Carl Rosow
Local Anesthetics
Ging Kuo Wang
Neuromuscular Blocking Agents and General Anesthesia
Gerald A. Gronert and Timothy Tautz
VI. Future Research
The Future of Anesthetic Mechanisms Research
Joseph F. Antognini, Douglas E. Raines, and Earl Carstens
Index