Description
Springer New Concepts of a Blood Brain Barrier 1st Editon 2014 Softbound by D.J. Begley, J. Greenwood, M. Segal
The scientific contribution of Mike Bradbury to the study of the blood-brain barrier is considerable and wide-ranging, starting with his M.D. thesis in 1962 and still continuing today. The varied spectrum of topics relating to the blood-brain barrier presented in this volume and the many geographical locations from which both speakers and participants gathered to attend the symposium are a fitting testament both to Mike's wide-spread influence in the field and to the esteem in which he is held. When we first had the idea of afestschrift to mark Mike's retirement as Professor of Physiology at King's College London and the beginning of a new vie libre as scientist and yachtsman the plan was initially for a gathering of all of the many colleagues, collaborators and students who had worked with him over the years. However what we had not taken into account was the closeness of the international community of workers in the field, the widespread influence that Mike had wielded and the speed with which word would spread. We should have anticipated all three. The final outcome was an excellent symposium with the majority of the world's key workers either contributing or attending. We hope that this volume presents an adequate record of the meeting. Developing Views of the Blood-Brain Barrier.- Development of the Blood-Brain Barrier.- Electrical Resistance Measurements of Blood-Brain Barrier Permeability.- The Application of Quantitative Immunocytochemistry for the Evaluation of Blood-Brain Barrier (BBB) to Endogenous Albumin.- Endothelin as a Mediator of Blood-Brain Barrier Function.- The Role of the Endothelial Cell Surface Charge for Blood-Brain Barrier Function.- Capillary Permeability in Central and Peripheral Nerve Tissue in Streptozotocin Diabetes in the Anaesthetised Rat.- Serotonin as a Mediator of Increased Microvascular Permeability of the Brain and Spinal Cord.- Molecular Regulation of Blood-Brain Barrier GLUT1 Glucose Transporter.- The Dependency of Influx Across the Blood-Brain Barrier on Blood Flow and the Apparent Flow-Independence of Glucose Influx During Stress.- Brain-Blood Barrier Removal of DOPA: Role in Regulation of Dopamine Synthesis and Treatment of Parkinson’s Disease.- Peptide Transport System-1.- Long-Chain Fatty Acid Transport at the Blood-Brain Barrier and Incorporation into Brain Phospholipids: A New In Vivo Method for Examining Neuroplasticity, and Brain Second Messenger Systems Involving Phospholipase A2 Activation.- Haemostatic Functions of the Blood-Brain Barrier: Possible Implications in the Pathogenesis of Stroke.- Autacoids as Mediators of Vasogenic Brain Oedema.- Blood-Brain Barrier Sodium Transport and Brain Edema Formation.- Mechanisms and Control of Blood-Brain Potassium Transport.- Transport of the Nucleoside, Thymidine, in the Central Nervous System: The Blood-Cerebrospinal Fluid and Blood-Brain Barriers.- Nasal Cerebrospinal Fluid Drainage in Man.- Pathophysiology and Treatment of Early-Onset Hydrocephalus in a Rat Model.- The Filtration Concept of the Blood-CSF-Barrier as Basis for the Differentiation of CSF Proteins.- Biophysics of Protein Diffusion from Blood into CSF: The Modulation by CSF Flow Rate.- Isolated Brain Microvessels and Cultured Cerebral Endothelial Cells in Blood-Brain Barrier Research: 20 Years On.- Studies on an Immortalized Brain Endothelial Cell Line: Characterization, Permeability and Transport.- Designing Drugs for Optimal Nervous System Activity.- Carrier-Mediated Drug Transport at the Blood-Brain Barrier and the Potential for Drug Targeting to the Brain.- Blood-Brain Barrier Manipulation: Current Status of Laboratory and Clinical Studies.- Peripheral Tissue Grafts as Portals into Brain for Solutes and Leukocytes.- CNS Transplants and the Host Immune Response: The Blood-Brain Barrier and Immunological Privilege within the Mammalian Brain.- The Blood-Brain Barrier—No Barrier to a Determined Lymphocyte.- The Blood-Retinal Barrier in Immune-Mediated Diseases of the Retina.