Description
Humana Press Inc. Pathogenesis Of Neurodegenerative Disorders by Mark P. Mattson
As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.
Mechanisms of Neuronal Apoptosis and Excitotoxicity
Mark P. Mattson
Oxidative Alterations in Neurodegenerative Diseases
William R. Markesbery, Thomas J. Montine, and Mark A. Lovell
Parkinson's Disease
M. T. Silva and A. H. V. Schapira
Scope of Trinucleotide Repeat Disorders
Shoji Tsuji
Mechanisms of Neuronal Death in Huntington's Disease
Vassilis E. Koliatsos, Carlos Portera-Cailliau, Gabrielle Schilling, David B. Borchelt, Mark W. Becher, and Christopher A. Ross
Cellular and Molecular Mechanisms Underlying Synaptic Degeneration and Neuronal Death in Alzheimer's Disease
Mark P. Mattson, Ward A. Pedersen, and Carsten Culmsee
Oxidative Stress in Down Syndrome: A Paradigm for the Pathogenesis of Neurodegenerative Disorders
Rocco C. Iannello and Ismail Kola
The Pathogenesis of Amyotrophic Lateral Sclerosis
Stanley H. Appel and R. Glenn Smith
Experimental Genetics as a Tool for Understanding Pathogenesis of ALS
Philip C. Wong, Donald L. Price, and Jamuna Subramaniam
Pathogenesis of Ischemic Stroke
Mark P. Mattson and Carsten Culmsee
Spinal-Cord Injury
Isabel Klusman and Martin E. Schwab
The Pathogenesis of Duchenne Muscular Dystrophy
Edward A. Burton and Kay E. Davies