Description
Taylor & Francis Process Chemistry in the Pharmaceutical Industry 1999 Edition by Kumar Gadamasetti
Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers-offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, Process Chemistry in the Pharmaceutical Industry is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists pharmacists and upper-level undergraduate and graduate students in these disciplines. Table of contents :- OverviewProcess Chemistry in the Pharmaceutical Industry: An Overview, Kumar G. GadamasettiStrategyProcess Research and Development Strategy for Accelerated Projects, Christopher M. CimarustiCase StudiesA Practical Synthesis of Ifetroban Sodium, Richard H. MuellerSynthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and Richard MatsuokaChemistry of Vitamin D: A Challenging Field for Process Research, Masami OkabeA Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator, Hans-Jurgen Federsel and Edib JakupovicOntazolast: The Evolution of a Process, Vittorio Farina, Karl Grozinger, Hermann Muller-Boetticher and Gregory P. RothDilevalol Hydrochloride: Development of a Commercial Process, Derek WalkerDesign and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist, Michael J. Martinelli and David L. VarieProcess Research and Development of CGS 19755, an NMDA Antagonist, Peter Giannousis, John Carlson and Marius LeimerRoute Evaluation for the Production of (R)-Levoprotiline, H. U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B. Schmitz, F. Spindler and Hj. WetterThe Process Research and Development of DuPont Merck's Cyclic Urea Diols, A New Class of HIV Protease Inhibitors, Pat N. Confalone and Robert E. WaltermirePractical Enantio- and Diastereo-selective Processes for Azetidinones, T. K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong WuSynthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors, Ian M. McFarlane, Christopher G. Newton and Philippe PitchenEnzymatic Intervention and Phase Transfer CatalysisChemistry, Biocatalysis and Engineering: An Interdisciplinary Approach to the Manufacture of the Benzodiazepine Drug Candidate LY 300164, Benjamin A. Anderson, Marvin M. Hansen, Jeffrey T. Vicenzi and Milton J. ZmijewskiBenefits and Challenges of Applying Phase-Transfer Catalysis Technology in the Pharmaceutical Industry, Marc E. HalpernAsymmetric Synthesis and EnantioselectivityEnantioselective Synthesis: The Optimum Process, John J. Partridge and Brian L. BrayPractical Catalysts for Asymmetric Synthesis: Ligands from Natural Sugars for Rh-Catalyzed Asymmetric Synthesis of D- and L- Amino Acids, Timothy A. Ayers and T. V. Rajan BabuChiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis, Chris H. Senanayake and Eric N. JacobsenDrug Substance Final Form and Process SafetyChemical Development of the Drug Substance Solid Form, Michael D. Thompson and Jean-Rene AuthelinThe Basic Principles of Thermal Process Safety: Towards a Better Communication Between Safety Experts and Process Chemists, Wilfried HoffmannDesign of Experiments and AutomationUsing Factorial Experiments in the Development of Process Chemistry, Daniel R. PilipauskasLaboratory Automation in Chemical Development, Martin R. Owen and Sheila H. Dewitt