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Springer Prostaglandins and Fertility Regulation 1st Editon 2011 Softbound by M. Toppozada, M. Bygdeman, E.S. Hafez
The role of prostaglandins in physiological events and pathological disorders related to human reproduction has been most actively investigated in the past decade. Their clinical use for fertility regulation, extensively evaluated, represents the most common clinical indication for the administration of these remarkable compounds. Thus, it is most appropriate to update the available information related to the use of prostaglandins in the regulation of human fertility to provide a background document for the benefit of clinicians and scientists. Invited experts of international reputation from various parts of the world have contributed, each in his own area of interest, to offer this book, which we hope will fill an existing gap. M. T. M. B. E. S. E. H. ix 1 Potential for prostaglandin use in controlling human reproduction K. T. KIRTON and F. A. KIMBALL BACKGROUND It was observed in 1930 that seminal plasma of a number of species contained very large amounts of substance(s) capable of altering uterine motility. These substances were subsequently demonstrated to be prostaglandins (PGs); this began the early and continued association of this group of compounds with reproduction. The activity was found to be associated with a fraction containing lipid-soluble acids, derived from prostanoic acid. Restrictions imposed by obscure sources and small amounts of material available for testing were initially impediments to their study. Section I Physio-pharmacological Parameters.- 1 Potential for prostaglandin use in controlling human reproduction.- 2 Metabolism and pharmacokinetics of prostaglandin analogs in man.- 3 Prostaglandins in the regulation of non-pregnant uterine contractility.- 4 Effects of Prostaglandins on the human non-pregnant uterus and ovary.- 5 Prostaglandin-induced changes in the pregnant human cer.- 6 Interaction between Prostaglandins and catecholamines on cervical collagen.- Section II Clinical Application.- 7 Self-administration at home of Prostaglandin for termination of early pregnancy.- 8 Menstrual induction and cervical priming prior to evacuation.- 9 Intra-amniotic Prostaglandins for mid-trimester abortion.- 10 Intramuscular administration of 15-methyl Prostaglandin F2? and laminaria insertion for termination of midtrimester pregnancy.- 11 Side-effects of natural Prostaglandins.- 12 Epilogue.