Description
Humana Protein Structure Stability And Folding 2001 Edition by Kenneth P. Murphy
In Protein Structure Stability and Folding Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents novel applications of hydrogen exchange techniques temperature-jump methods for looking at folding events and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice Protein Structure Stability and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today. Table of contents : Stabilization of Protein StructureKenneth P. MurphyProtein Stabilization by Naturally Occurring OsmolytesD. Wayne BolenThe Thermodynamic Linkage Between Protein Structure Stability and FunctionErnesto FreireMeasuring the Conformational Stability of a Protein by Hydrogen ExchangeBeatrice M.P. Huyghues-Despointes C. Nick Pace S. Walter Englander and J. Martin ScholtzModeling the Native State EnsembleVincent J. HilserConformational Entropy in Protein Folding: A Guide to Estimating Conformational Entropy via Modeling and ComputationTrevor P. CreamerTurn Scanning: Experimental and Theoretical Approaches to the Role of TurnsCarl Frieden Enoch S. Huang and Jay W. PonderLaser Temperature-Jump Methods for Studying Folding DynamicsJames HofrichterKinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native ProteinsT. Sivaraman and Andrew D. RobertsonMolecular Dynamics Simulations of Protein Unfolding/FoldingValerie Daggett