Description
Humana Studies On Cardiovascular Disorders 2010 Edition by Heinrich Sauer Ajay M. Shah Francisco R. M. Laurindo
The role of reactive oxygen species (ROS) in the cardiovascular system is Jan- faced. Whereas low concentrations of ROS are involved in variety of physiological signalling events oxidative stress resulting from deregulated overproduction of ROS and/or impaired antioxidant defences contributes to cardiovascular disease. The actions of ROS in the cardiovascular system are a fascinating topic not only for the basic science researcher but also for the clinician who is interested in seeking new therapies for his patients suffering from cardiovascular disease. The current book provides a comprehensive overview of the molecular mechanisms and pathoph- iological settings in which chronic and detrimental oxidative stress arises within the heart and vasculature. The book also considers currently discussed strategies in avoiding chronic redox stress resulting from exposure to risk factors or various cardiovascular interventions. The series starts with an overview by Denise de Castro Fernandes Diego Bonatto and Francisco Laurindo of redox signaling models that could underlie the dev- opment of redox-associated cardiovascular disorders.The interactions of proteins within signalling cascades with ROS and the regulation of such interactions by the anti-oxidative capacity of the cell are discussed. Rebecca Charles Joseph Burgoyne and Philip Eaton report on redox-mediated modi cations of proteins under ph- iological and pathophysiological conditions and the variety of post-translational oxidative modi cations that explain redox sensing and signal transduction by proteins at the molecular level. ROS are generated during embryogenesis and may be involved in the proper development of the cardiovascular system. Table of contents : PrefaceContributor's ListChapters:1) The evolving concept of oxidative stressDenise de Castro Fernandes Diego Bonatto Francisco R. M. Laurindo2) Mechanisms of redox signaling in cardiovascular diseaseRebecca L. Charles Joseph R. Burgoyne and Philip Eaton3) Reactive oxygen and nitrogen species in cardiovascular differentiation of stem cellsHeinrich Sauer and Maria Wartenberg4) Reactive Oxygen Species (ROS) and the sensory neurovascular componentRabea Graepel BSc Jennifer Victoria Bodkin BSc MRes & Susan Diana Brain BSc PhD5) Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Post-ConditioningAriel R. Cardoso Bruno B. Queliconi* and Alicia J. Kowaltowski6) Coenzyme Q9/Q10 and Healthy HeartSamarjit Das Somak Das and Dipak K. Das7) Oxidative and proteolytic stress in homocysteine associated cardiovascular diseasesKarni S. Moshal Munish Kumar Neetu Tyagi Paras Kumar Mishra Saumi Kundu Suresh C. Tyagi8) Functional studies of NADPH oxidases in human vasculatureTomasz J Guzik9) Relationship of the CYBA gene polymorphisms with oxidative stress and cardiovascular riskGuillermo Zalba PhD and Javier Diez MD PhD10) Redox-related genetic markers of cardiovascular diseasesChristian Delles MD and Anna F. Dominiczak MD11) NADPH oxidases and blood-brain barrier dysfunction in strokeTimo Kahles MD Sabine Heumuller and Ralf P. Brandes MD12) Smoking-Induced Oxidative Stress in the Pathogenesis of Cardiovascular DiseasesDavid Bernhard PhD13) Oxidative Stress in Vascular AgingAnna Csiszar MD PhD and Zoltan Ungvari MD PhD14) Oxidative Stress and Cardiovascular Disease in Diabetes MellitusDivya Gupta Kathy K. Griendling and W. Robert Taylor15) Reactive Oxygen Species Oxidative Stress and HypertensionRhian M Touyz MD PhD Andreia Chignalia MSc Mona Sedeek PhD16) Peripartum cardiomyopathy: Role of STAT-3 and reactive oxygen speciesDenise Hilfiker-Kleiner PhD Arash Haghikia MD andAndres Hilfiker PhD17) Oxidative stress and inflammation after coronary angiographyRaymond Farah MD18) Oxidative Stress in Cardiac TransplantationGalen M. Pieper Ph.D. and Ashwani K. Khanna Ph.D19) Oxidative Stress and Atrial FibrillationAli A. Sovari and Samuel C. Dudley Jr.20) Oxidative stress and the anti-oxidative capacity in myocardial infarctionYao Sun MD Ph.D.21) Oxidative Stress and Redox Signalling in Cardiac RemodellingMin Zhang MD PhD Alex Sirker MRCP and Ajay M Shah MD FmedSci22) Oxidative Stress and Cardiovascular FibrosisSubramanian Pennathur Louise Hecker and Victor J. Thannickal23) Oxidative Risk Factors for Cardiovascular Disease in WomenM. Gago-Dominguez Xuejuan Jiang J. Esteban Castelao24) Protective effects of food on cardiovascular diseasesAlfonso Giovane Biol.D. Ph.D. and Claudio Napoli M.D. Ph.D. MBEth.25) Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic ImplicationsGloria V. Lopez PhD and Homero Rubbo PhD26) Thioredoxin in the cardiovascular system - towards a thioredoxin-based anti-oxidative therapyBradford C. Berk27) The protective effect of melatonin on the heartAmanda Lochner28) Exercise Induced cardioprotection: Overview with an emphasis on the role of anti-oxidantsKaryn L. Hamilton and John C. Quindry29) Antioxidative properties of statins in the heartOliver Adam MD Ulrich Laufs MD