Description
SPRINGER Supramolecules In Drug Discovery And Drug Delivery Methods And Protocols (Pb 2021) by MAVROMOUSTAKOS T.
This detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems. Beginning with a collection of chapters on drug delivery platforms such as cyclodextrins, micelles, liposomes, polymeric, nanotubes, and more, the volume continues with coverage of the study of nanotechnology systems using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and electrochemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols serves as an ideal guide for researchers working toward drug delivery mechanisms that can tailor their physical chemical properties and enhance their efficacy, while retaining their structures intact. 1. Application of Neutralization and Freeze-Drying Technique for the Preparation of the Beneficially in the Drug Delivery 2-Hydroxypropyl- -Cyclodextrin Complexes with Bioactive MoleculesEirini Christodoulou, Dimitrios Ntountaniotis, Georgios Leonis, Thomas Mavromoustakos, and Georgia Valsami2. Functionalized Carbon Nanohorns as Drug Delivery PlatformsAnastasios Stergiou and Nikos Tagmatarchis3. Ultrasonics-Assisted Effective Isolation and Characterization of Exosomes from Whole OrgansBurak Derkus and Emel Emregul4. Aggregate Determination by Permeation TechniquePhennapha Saokham and Thorsteinn Loftsson5. Study of Candesartan Cilexitil:2-Hydroxypropyl- -Cyclodextrin Interactions: A Computational Approach Using Steered Molecular Dynamics SimulationsSofia Kiriakidi and Thomas Mavromoustakos6. Drug Delivery: Hydrophobic Drug Encapsulation into Amphiphilic Block Copolymer MicellesAngeliki Chroni, Varvara Chrysostomou, Athanasios Skandalis, and Stergios Pispas7. Multisensitive Polymeric Nanocontainers as Drug Delivery Systems: Biological EvaluationMaria Theodosiou, Theodora Koutsikou, and Eleni K. Efthimiadou8. Drug Incorporation in the Drug Delivery System of MicellesEvangelia Soumelidou, Simona Golic Grdadolnik, and Thomas Mavromoustakos9. Molecular Dynamics Protocols for the Study of Cyclodextrin Drug Delivery SystemsGeorge Leonis, Dimitris Ntountaniotis, Eirhnh Christodoulou, and Thomas Mavromoustakos10. Drug Delivery through Multifunctional Polypeptidic HydrogelsHermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki, and Barbara Athanasiou11. Polymersomes from Hybrids-Polypeptides for Drug Delivery ApplicationsHermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki, and Barbara Athanasiou12. Drug Delivery Systems Based on Modified Polysaccharides: Synthesis and CharacterizationAikaterini-Foteini Metaxa, Eleni Vrontaki, Eleni Efthimiadou, and Thomas Mavromoustakos13. Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery FormulationsNikolaos Naziris, Maria Chountoulesi, Dimitrios Ntountaniotis, Thomas Mavromoustakos, and Costas Demetzos14. Encapsulation of Small Drugs in a Supramolecule Enhances Solubility, Stability, and Therapeutic Efficacy against Glioblastoma MultiformeAntonis D. Tsiailanis, Alexander Renziehausen, Serdar Karakurt, Tim Crook, Nelofer Syed, and Andreas G. Tzakos15. Unveiling the Thermodynamic Aspects of Drug-Cyclodextrin Interactions through Isothermal Titration CalorimetryMaria V. Chatziathanasiadou, Thomas Mavromoustakos, and Andreas G. Tzakos16. Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin EstersAli Ben Taleb, Selcan Karakus, Ezgi Tan, Merve Ilgar , OEzlem Kutlu, Devrim Goezuacik, Hatice Mehtap Kutlu, and Ayben Kilislioglu17. Association of the Thermodynamics with the Functionality of Thermoresponsive Chimeric NanosystemsNikolaos Naziris, Athanasios Skandalis, Thomas Mavromoustakos, Stergios Pispas, and Costas Demetzos18. 2D DOSY NMR: A Valuable Tool to Confirm the Complexation in Drug Delivery SystemsChristos . Chatzigiannis, Sofia Kiriakidi, Andreas G. Tzakos, and Thomas Mavromoustakos19. Drug-Encapsulated Cyclodextrin NanospongesMaria Tannous, Fabrizio Caldera, Gjylije Hoti, Umberto Dianzani, Roberta Cavalli, and Francesco Trotta20. Electrochemistry Investigation of Drugs Encapsulated in CyclodextrinsRomana Sokolova and Ilaria Degano21. A Differential Scanning Calorimetry (DSC) Experimental Protocol for Evaluating the Modified Thermotropic Behavior of Liposomes with Incorporated Guest MoleculesMaria Chountoulesi, Nikolaos Naziris, Thomas Mavromoustakos, and Costas Demetzos22. Applications of NMR in Drug:Cyclodextrin ComplexesDimitrios Ntountaniotis, George Leonis, Eirinh Christodoulou, and Thomas Mavromoustakos23. Construction of Peptide-Drug Conjugates for Selective Targeting of Malignant Tumor CellsEirinaios I. Vrettos and Andreas G. Tzakos