Description
Taylor & Francis The Blood-Brain Barrier and Drug Delivery to the CNS 2000 Edition by Michael Bradbury, David Begley, Jorg Kreuter
This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research.Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNSassesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more!Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines. Table of contents :- History and Physiology of the Blood-Brain Barrier in Relation to Delivery of Drugs to the BrainMichael W. BradburyPhysicochemical Factors that Influence Brain UptakeMichael H. Abraham and James A. PlattsThe Development of In Vitro Models for the Blood-Brain and Blood-CSF BarriersChristiane Engelbertz, Dorothea Korte, Thorsten Nitz, Helmut Franke, Matthias Haselbach, Joachim Wegener, and Hans-Joachim GallaIn Vitro Models of the Blood-Brain Barrier and Their Use in Drug DevelopmentR. Cecchelli, B. Dehouck, L. Descamps, L. Fenart, V. Buee-Scherrer, C. Duhem, G. Torpier, and M. P. DehouckThe Application of Microdialysis Techniques to the Study of Drug Transport Across the Blood-Brain BarrierA. G. de Boer, Elizabeth C. M. de Lange, Inez C. J. van der Sandt, and Douwe D. BreimerThe Role of Brain Extracellular Fluid Production and Efflux Mechanisms in Drug Transport to the BrainDavid J. Begley, Anthony Regina, Francoise Roux, Ehsan Ullah Khan, Christopher Rollinson, and Joan AbbottThe Relevance of P-Glycoprotein in Drug Transport to the Brain: The Use of Knockout Mice as a Model SystemUlrich MayerSpecific Mechanisms for Transporting Drugs Into BrainAkira TsujiDrug Metabolism in the Brain: Benefits and RisksAlain Minn, Ramon D. S. El-Bacha, Claire Bayol-Denizot, Philippe Lagrange, Funmilayo G. Suleman, and Daniela GradinaruTargeting Macromolecules to the Central Nervous SystemUlrich BickelUsing Nanoparticles to Target Drugs to the Central Nervous SystemJoerg Kreuter and Renad N. AlyautdinBasic CNS Drug Transport and Binding Kinetics In VivoAlbert Gjedde, Antony D. Gee, and Donald Frederick Smith