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Springer The Neutrophil 1st Editon 2013 Softbound by Patrick Murphy
This book reflects the personal prejudices I have developed in twenty years of reading the scientific literature. I like monographs; good ones assemble a great deal of information in a logical sequence and in enough detail to enable one to see why current beliefs are held. For this purpose, it is entirely useless to write 'as Smith has shown21 ,81,117 •••• ' That only means that one must go to the library and turn up Smith's original papers, and one's object in reading a monograph is precisely to avoid that neces sity. One needs to know what Smith did and why he thought his observa tions proved whatever he claimed. Because life is short, it is impossible to deal with several thousand papers in this way, and the author must there fore select a relatively few papers that he regards as crucial. Often, several papers of equal merit might be quoted, and the selection is then arbitrary. I therefore apologize to authorities who do not find their work discussed. Omission does not mean that I thought their work was not valuable; it means only that I preferred to quote twenty references that people might read rather than two thousand that assuredly no one would read. Another strong prejUdice is that the full understanding of present knowledge requires one to know how present views have developed. 1 Blood Cells.- 1.1. Platelets.- 1.2. White Cells.- Selected Reading.- 2 Morphology and Cellular Physiology of Neutrophil Granulocytes.- 2.1. The Nucleus.- 2.2. Nucleic Acid Metabolism.- 2.3. The Cytoplasm.- 2.4. The Granules.- 2.5. Cell Movement.- 2.6. Directed Cell Movement.- 2.7. Microtubules and Degranulation.- 2.8. The Cell Membrane.- Selected Reading.- 3 The Origin and Development of Neutrophils.- 3.1. The Bone Marrow and Neutrophil Precursors.- 3.2. Rates of Cell Division in Neutrophil Precursors.- 3.3. Neutrophil Precursors Which Cannot Be Recognized Morphologically.- 3.4. Summary.- Selected Reading.- 4 Tissue Consumption of Granulocytes and Control Mechanisms for Granulopoiesis.- 4.1. Distribution, Function, and Disposal of Neutrophils.- 4.2. Control of the Blood Neutrophil Level.- 4.3. Summary.- 5 Inflammation and Chemotaxis.- 5.1. Inflammation.- 5.2. Chemotaxis.- 5.3. Antagonists of Inflammation.- 5.4. Summary.- Selected Reading.- 6 Phagocytosis.- 6.1. Mechanisms of Phagocytosis.- 6.2. Physiological Significance of Phagocytic Mechanisms.- 6.3. Summary.- 7 Degranulation and Intracellular Killing of Bacteria.- 7.1. Historical Aspects.- 7.2. Phagocytin.- 7.3. Degranulation.- 7.4. Intracellular Killing of Bacteria.- 7.5. Summary.- 8 Other Activities of Neutrophils.- 8.1. Extracellular Release of Neutrophil Granule Contents.- 8.2. Enzymes Responsible for Tissue Damage.- 8.3. Abscess Formation.- 8.4. The Arthus Reaction.- 8.5. Nephrotoxic Nephritis.- 8.6. Serum Sickness.- 8.7. The Schwartzman Reaction.- 8.8. Human Diseases Involving Neutrophils.- 8.9. Neutrophils and Tissue Repair.- 8.10. Fever and Other Hormonally Mediated Responses to Infection.- References.