Description
Humana Press Thrombolytic Therapy For Acute Stroke by Patrick D. Lyden
It often takes time for a new therapeutic modality to mature into an accepted treatment option. After initial approval, new drugs, devices, and procedures all go through this process until they become "vetted" by the scientific community as well as the medical community at large. Thrombolysis for treatment of stroke is no exception. Thrombolytic Therapy for Acute Stroke, Second Edition comes four years after the first edition and provides a very comprehensive, updated perspective on the use of intravenous rt-TPA in acute stroke. The authors provide longer term follow-up on the pivotal clinical trials that led to Food and Drug Administration approval, data concerning phase 4 trials in larger numbers of patients, and, most importantly, the community experience that has accumulated since its release. They add to this the latest promising information concerning intra-arterial thrombolysis, which is still under investigation and more speculative sections concerning possible new avenues of clinical research such as combining intravenous thr- bolysis with neuroprotective therapies or intra-arterial thrombolysis. A wealth of factual information is supplemented by chapters containing sage opinion from Drs. Lyden and Caplan concerning the logistical, economic, and procedural issues that have been generated since the advent of this technology. Importantly, diagnosis does not take a back seat to therapeutics as illustrated by sections devoted to eva- ation of the stroke patient, very useful illustrative cases and clinical comments, and chapters on the latest in imaging as applied to this field.show more Part I: Background and Basic InvestigationsMechanisms of ThrombolysisGregory J. del Zoppo and Naohisa HosomiPathology of Cervico-Cranial Artery OcclusionLouis R. CaplanThe Ischemic Penumbra and Neuronal SalvagePatrick D. LydenPart II: Scientific Rationale and Clinical TrialsPre-Clinical Testing of Thrombolytic Therapy for Acute Ischemic StrokeSteven R. LevineCombination of Thrombolytic Therapy With NeuroprotectantsJames C. Grotta and Lise A. LabichePilot and Preliminary Studies of Thrombolytic Therapy for StrokeSteven R. Levine, E. Clarke Haley, and Patrick D. LydenIntravenous Thrombolytic Therapy for Acute Ischemic Stroke: Results of Large Randomized Clinical TrialsMatthew L. Flaherty, Edward C. Jauch, Rashmi U. Kothari, and Joseph P. BroderickFurther Analysis of NINDS Study: Long-Term Outcome, Subgroups, and Cost EffectivenessSusan C. Fagan, Thomas D. Kwiatkowski, and Patrick D. LydenCommunity Experience With Intravenous Thrombolysis for Acute StrokeLama Al-Khoury and Christy M. JacksonIntra-Arterial Thrombolysis in Acute Ischemic StrokeAnthony J. Furlan, Randall Higashida, Irene Katzan, Alex Abou-Chebl, and Andrew N. RussmanCombinations of Intravenous and Intra-Arterial ThrombolysisMatthew L. Flaherty and Joseph BroderickPart III: Using Thrombolysis for Acute StrokeThrombolysis in Vertebrobasilar Occulsive DiseaseLouis R. CaplanThrombolytic Therapy in Stroke PatientsPatrick D. LydenStroke Thrombolysis: The Present Guidelines and Policies for Clinical Use Should Be ChangedLouis R. CaplanHow to Run a Stroke CodeAskiel BrunoThe Impact of Computed Tomography on Acute Stroke TreatmentRudiger von KummerUsing Magnetic Resonance Imaging to Select andManage Patients for TreatmentPeter D. Schellinger, Chelsea S. Kidwell, and Steven WarachThe rt-PA for Acute Stroke ProtocolJohn Marler and Patrick D. LydenPart IV: Illustrative CasesIllustrative CasesIndex