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Humana Press Inc Transgenic And Knockout Models Of Neuropsychiatric Disorders by Gene S. Fisch
In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Protein Tyrosine Kinases as Targets for Cancer and Other IndicationsMark Pearson, Carlos Garcia-Echeverria, and Doriano FabbroInhibitors of Signaling Interfaces: Targeting Src Homology 2 Domains in Drug DiscoveryCarlos Garcia-EcheverriaPI3-Kinase Inhibition: A Target for Therapeutic InterventionPeter M. Finan and Stephen G. WardSrc as a Target for Pharmaceutical Intervention: Potential and LimitationsMira Susa, Martin Missbach, Rainer Gamse, Michaela Kneissel, Thomas Buhl, Jurg A. Gasser, Markus Glatt, Terence O'Reilly, Anna Teti, and Jonathan GreenActivated FLT3 Receptor Tyrosine Kinase as a Therapeutic Target in LeukemiaBlanca Scheijen and James D. GriffinJAK Kinases in Leukemias, Lymphomas, and Multiple MyelomaRenate Burger and Martin GramatzkiGlivec (R) (Gleevec (R), Imatinib, STI571): A Targeted Therapy for Chronic Myelogenous LeukemiaElisabeth Buchdunger and Renaud CapedevillePlatelet-Derived Growth Factor: Normal Function, Role in Disease, and Application of PDGF AntagonistsTobias Sjoeblom, Kristian Pietras, Arne OEstman, and Carl-Henrik HeldinStructural Biology of Protein Tyrosine KinasesSandra W. Cowan-Jacob, Paul Ramage, Wilhelm Stark, Gabriele Fendrich, and Wolfgang JahnkeTesting of Signal Transduction Inhibitors in Animal Models of CancerTerence O'Reilly and Robert CozensPhosphoproteomics in Drug Discovery and DevelopmentMichel F. Moran, Jarrod A. Marto, Cynthia J. Brame, Olga Ornatsky, Mark M. Ross, Leticia M. Toledo-Sherman, Alfredo C. Castro, Brett Larsen, Henry Duewel, Christopher Hosfield, Christopher Orsi, Thodoros Topaloglou, Daniel Figeys, Jarrod A. Caldwell-Busby, and David R. StoverIndex