Description
Springer Treatment of Radiation Injuries 1st Editon 2013 Softbound by Doris Browne
The proliferation of radioactive materials in industry, in diagnostic and therapeutic medicine, in scientific and medical research, in the military, and as a source of energy has increased the likelihood of accidental exposure to ionizing radiation. Further, the number of individuals exposed in accidents, such as Chernobyl, U. S. S. R. ; Goiania, Brazil; and San Salvador, El Salvador, underscores the potential for large-scale radiation accidents. Because of these accidents, health care providers have found themselves treating patients with acute radiation injuries and subsequent complications. Often the radiation injuries are combined with burns or other trauma and the infectious and immune complications associated with such injuries. The treatment of victims of these accidents has provided important information about the medical management of radiation casualties. However, development of techniques to improve the diagnosis and treatment of radiation injuries, to collect follow up data on survivors, and to determine the long-term effects of uncontrolled radiation exposure must continue. The Armed Forces Radiobiology Research Institute, Bethesda, Maryland, and its Medical Radiobiology Advisory Team sponsored the First Consensus Development Conference on the Treatment of Radiation Injuries in Washington, DC, on May 10-13, 1989. The proceedings of the conference are presented in this volume, which we hope will serve as a reference for clinicians and basic research scientists who require knowledge of the latest developments in the diagnosis and treatment of radiation injuries. This conference was designed specifically to address the areas of hematopoietic injury, infectious complications, and combined injury. Hematopoietic Injury Complications.- Medical Assessment and Therapy in Bone Marrow Failure Due to Radiation Accidents: Role of Bone Marrow Transplantation and Hematopoietic Growth Factors.- Use of rhGM-CSF in Bone Marrow Failure: Is There a Therapeutic Role for GM-CSF in Accidental Radiation Injuries?.- Blood and Bone Marrow Products in the Treatment of Radiation Injury.- Total-Body Irradiation in Bone Marrow Transplantation.- Rescue of Lethally Irradiated Animals: Therapeutic Use of rhG-CSF and rhGM-CSF in Preclinical Models of Radiation-Induced Marrow Aplasia.- Myeloprotective Effects of Interleukin-1 Following Exposure to Chemoradiotherapy.- Effects of Combined Application of IL-3 and G-CSF on Subhuman Primates.- Infectious Complications.- Infections in Radiation Accidents: An Overview.- Antibiotics in Postirradiation Infection.- Treatment of Infectious Complications of the Hematopoietic Syndrome.- Role of Immunotherapy in Preventing and Managing Postirradiation Infections.- Management of Fungal Infections Complicating Granulocytopenia: Implications for Patients With Radiation Injuries.- Prevention of Infection With Endogenous Organisms.- Role of Hematopoietic Growth Factors in Radiation Victims: RhGM-CSF Following the Goiânia Accident.- Combined Injury Complications.- The Status of Combined Injuries.- Combined Radiation and Thermal Injury After Nuclear Attack.- Complications of Combined Injury: Radiation Damage and Skin Wound Trauma in Mouse Models.- Wound Environment: Implications for Healing and Infection.- Future Directions and Consensus Summary Statement.- A Historical Perspective on the Therapy of Total-Body Radiation Injury.- Acute Effects of Radiation Exposure Following the Chernobyl Accident: Immediate Results of Radiation Sickness and Outcome of Treatment.- Potential Role for Human Colony-Stimulating Factors in the Treatment of Radiation Injuries.- Consensus Summary Statement on the Treatment of Radiation Injuries.- Appendixes.- Appendix A: Consensus Panel Participants.- Appendix B: Conference Participants.