Description
Taylor & Francis Tumor Angiogenesis and Microcirculation 2001 Edition by Emile E. Voest, Patricia A. D'Amore
Compiling the latest developments in anticancer therapies based on the connection between tumor and capillary growth, Tumor Angiogenesis and Microcirculation presents a comprehensive overview of diverse aspects of angiogenesis-related cancer research. Highlights the role angiogenesis and its inhibitors play in the growth, metastasis, and dormancy of tumors! Facilitating the progress of clinical practice with insights from methodological and scientific results, Tumor Angiogenesis and Microcirculation summarizes biological principles of angiogenesis and microcirculation, from endothelial cells and pericytes, and extracellular matrix regulation to matrix metalloproteinases (MMPs) and plasmin and plasmin inhibitorsexamines proangiogenic factors such as vascular endothelial (VEGF) and basic fibroblast (bFGF) growth factors, tie receptors, and cytokines outlines methods for discovering angiogenesis stimulators and inhibitor peptides, particularly the clinical development of thrombospondin, angiostatin, endostatin, and MMP inhibitors reveals the link between oncogenes and neoplastic angiogenesis and its regulation by the organ microenvironment investigates tumor vascularity in relation to tumor growth and the spread of cancerdetails promising future applications, including perspectives in vascular cancer therapyand more! Combining the resources of 60 recognized experts and nearly 3000 pertinent literature references, drawings, photographs, and x-rays, Tumor Angiogenesis and Microcirculation profits oncologists, pathologists, hematologists, and radiation and hemato-oncologists surgeons and internists cardiologists immunologists cell, molecular, and developmental biologists rheumatologists ophthalmologists dermatologists and medical school students in these disciplines. Table of contents : - Biological Principles of Angiogenesis Endothelial Cells and Pericytes in Tumor VasculatureDiane C. Darland and Patricia A. D'AmoreThe Extracellular Matrix and the Regulation of AngiogenesisJoseph A. MadriMatrix Metalloproteinases (Matrixins) and Their Inhibitors (TIMPS) in AngiogenesisTeresa A. Bennett and William G. Stetler-StevensonRegulation of Cell Migration in the Process of AngiogenesisBela Anand-Apte and Bruce R. ZetterPlasmin, Plasmin Inhibitors, and AngiogenesisMartijn F. B. G. GebbinkAssays to Study Angiogenesis Assays to Study AngiogenesisRobert Auerbach and Wanda AuerbachScreening for Angiogenesis Inhibitors with the Chick Chorioallantoic Membrane and the Mouse Corneal Micropocket AssaysRobert J. D'AmatoCapillary Morphogenesis In Vitro: Cytokine Interactions and Balanced ProteolysisRoberto Montesano and Michael S. PepperSkin Fold Chamber ModelsMichael Leunig and Konrad MessmerProtease Assays and Their Use in the Discovery of Novel Regulators of AngiogenesisLi Yan, Inmin Wu, and Marsha A. MosesAngiogenic Factors Vascular Endothelial Growth Factor/Vascular Permeability Factor: Multiple Biological Activities for Promoting AngiogenesisDonald R. SengerTie Receptors, Ang LigandsYuji Gunji, Arja Kaipainen, Kristiina Iljin, Eola Kukk-Valdre, Berndt Enholm, and Kari AlitaloVascular Endothelial Growth Factor ReceptorsArja Kaipainen, Eija Korpelainen, and Kari AlitaloRegulation of Vascular Endothelial Growth Factor (VEGF) ExpressionIlan Stein and Eli KeshetFibroblast Growth FactorsDavid A. Moscatelli and Daniel B. RifkinRole of Proangiogenic Cytokines and Inhibitors of Neovascularization in Tumor AngiogenesisPeter J. Polverini and Robert M. StrieterRegulation of Angiogenesis The Link Between Oncogenes, Signal Transduction Therapy, and Tumor AngiogenesisRobert S. Kerbel, Alicia Viloria-Petit, Futoshi Okada, and Janusz RakGenetic Control of Angiogenesis by Tumor Suppressor GenesMaartje Los and Emile E. VoestRegulation of Neoplastic Angiogenesis by the Organ MicroenvironmentRakesh Kumar and Isaiah J. FidlerRole of Macrophages in Tumor AngiogenesisPeter J. PolveriniPhenotypic Analysis of Endothelium from the Tumor VasculatureGerard Groenewegen and Arjan W. GriffioenAngiogenesis Inhibitors: Preclinical and Clinical Drugs Drug Delivery and Angiogenesis Inhibition in the Treatment of Brain TumorsLaurence D. Rhines, Matthew G. Ewend, and Henry BremMatrix-Associated Endogenous Inhibitors of AngiogenesisRaghu Kalluri and Vikas P. Sukhatmevss? and Its Antagonists in the Control of AngiogenesisBrian P. Eliceiri and David A. ChereshThe Role of Vascular Endothelial Growth Factor in AngiogenesisNapoleone FerraraTNP-470: Preclinical and Clinical DevelopmentDeborah M. Milkowski and Rachelle A. WeissMatrix Metalloproteinase InhibitorsPeter D. BrownTumoral Vascularity: What Does It Tell Us About the Growth and Spread of Cancer?Noel WeidnerThe Prognostic and Diagnostic Value of Circulating Angiogenic Factors in Cancer PatientsOlaf A. J. Kerckhaert and Emile E. VoestFuture Perspectives Perspectives in Vascular Cancer Therapy: An IntroductionGeert H. BlijhamThe Combination of Antiangiogenic Therapy with Cytotoxic Therapy: A Systems ApproachBeverly A. TeicherTargeting the Vasculature of Solid TumorsPhilip E. Thorpe and Sophia RanCombining Antivascular Approaches with Radiotherapy: A PerspectiveJuliana DenekampAntiangiogenic Gene TherapyJaap C. Reijneveld and Emile E. Voest