Water Insoluble Drug Formulation 3rd Editon at Meripustak

Water Insoluble Drug Formulation 3rd Editon

Books from same Author: LIU R

Books from same Publisher: Taylor and Francis

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  • General Information  
    Author(s)LIU R
    PublisherTaylor and Francis
    Edition3rd Edition
    Publish YearMarch 2018


    Taylor and Francis Water Insoluble Drug Formulation 3rd Editon by LIU R

    Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement. Key Features:- - Reviews existing theories of interactions between solutes and solvents - Details the drug discovery support area for designing new drug candidates with improved aqueous solubility and maximized exposure - Describes the physiochemical and biopharmaceutical properties of water-insoluble drugs - Includes dissolution rate enhancement and related techniques for the development of oral solid dosage forms - Presents formulation techniques to enhance bioavailability for oral dosage forms - Demonstrates solubilization examples in parenteral applications Table of Contents Chapter 1 Introduction Rong (Ron) Liu Chapter 2 Solubility Theory Steven H. Neau Chapter 3 Prediction of Solubility Yisheng Chen, Xiaohong Qi, and Rong (Ron) Liu Chapter 4 Preformulation Aspects of Insoluble Compounds Wei-Qin (Tony) Tong and Hong Wen Chapter 5 Water-Insoluble Drugs and Their Pharmacokinetic Behaviors Honghui Zhou and Hao Zhu Chapter 6 Regulatory Aspects of Dissolution for Low Solubility Drug Products Pradeep Sathe, Robert A. Lionberger, Sau Lawrence Lee, Lawrence X. Yu, and Di (Doris) Zhang Chapter 7 Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support Lian-Feng Huang, Jinquan Dong, and Shyam B. Karki Chapter 8 Application of Complexation in Drug Development for Insoluble Compounds Wei-Qin (Tony) Tong and Hong Wen Chapter 9 Solubilization Using Cosolvent Approach Jay S. Trivedi and Zhanguo Yue Chapter 10 Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery・Part I: Parenteral Applications John B. Cannon, Yi Shi, and Pramod Gupta Chapter 11 Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery・Part II: Oral Applications John B. Cannon and Michelle A. Long Chapter 12 Micellization and Drug Solubility Enhancement Rong (Ron) Liu, Rose-Marie Dannenfelser, Shoufeng Li, and Zhanguo Yue Chapter 13 Polymeric Micelles in Water-Insoluble Drug Delivery Rong (Ron) Liu, M. Laird Forrest, Glen S. Kwon, Xiaobing Xiong, and Zhihong (John) Zhang Chapter 14 Liposomes in Solubilization Rong (Ron) Liu, John B. Cannon, and Sophia Y.L. Paspal Chapter 15 Pharmaceutical Salts Steven H. Neau and Nikhil C. Loka Chapter 16 Prodrugs for Improved Solubility in Water Steven H. Neau, Nikhil C. Loka, and Kalyan K. Saripella Chapter 17 Particle Size Reduction Xiang (Lisa) Li, Zhanguo Yue, Robert W. Lee, James McShane, J. Michael Shaw, Ray W. Wood, and Dinesh B. Shenoy Chapter 18 Development of Solid Dispersion for Poorly Water-Soluble Drugs Madhav Vasanthavada, Simerdeep Singh Gupta, Wei-Qin (Tony) Tong, and Abu T.M. Serajuddin Chapter 19 Alteration of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms Paul B. Myrdal, Stephen J. Franklin, and Michael J. Jozwiakowski Chapter 20 Pharmaceutical Powder Technology・ICH Q8 and Building the Pyramid of Knowledge Hans Leuenberger, Silvia Kocova El-Arini, and Gabriele Betz Chapter 21 Soft Gelatin Capsules Development S. Esmail Tabibi, Liangran Guo, and Shanker L. Gupta Chapter 22 Oral Modified-Release Drug Delivery for Water-Insoluble Drugs Shaoling Li, Nuo (Nolan) Wang, Rong (Ron) Liu, Zhanguo Yue, and Zhihong (John) Zhang Chapter 23 Scalable Manufacturing of Water-Insoluble Drug Products Nitin P. Pathak, Richard (Ruey-ching) Hwang, and Xiaohong Qi Index