Description
Humana Press Inc. Acute Myelogenous Leukemia by Judith E. Karp
This is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas._x000D_ _x000D_
TABLE OF CONTENTS_x000D_
_x000D_
I. Overview of AML: Francis Giles, MD Anderson_x000D_
II. Molecular Foundations of AML Pathogenesis and Pathophysiology_x000D_
A. Transcriptional Control of Myeloid Differentiation and Transformation: Alan Friedman, Johns Hopkins _x000D_
B. Myelodysplasia-Related AML: Ghulam Mufti, King's College, London, England_x000D_
C. Treatment-Related AML: Michelle LeBeau, University of Chicago_x000D_
D. DNA Damage and Repair: David Steensma and Scott Kaufmann Mayo Clinic_x000D_
E. Apoptosis: Ruben Mesa and Scott Kaufmann, Mayo Clinic_x000D_
F. Drug Resistance Transporters: Douglas Ross, University of Maryland_x000D_
III. Translating Biology into Clinical Application _x000D_
A. Impact of Cytogenetics on Clinical Outcome: David Grimwade, Guy's Hospital, London, England _x000D_
B. APL: A Classic Tale of Bench to Bedside: Martin Tallman, Northwestern _x000D_
C. Molecular Therapeutics of AML: Selected Targeted Approaches _x000D_
Overview: Edward Sausville, University of Maryland_x000D_
FLT3: Mark Levis, Johns Hopkins_x000D_
Farnesyltransferase: Jeffrey Lancet, Moffitt (University of South Florida)_x000D_
Modulating Gene Expression as a Therapeutic Approach: Tamer Fandy, _x000D_
Hetty Carraway, Steven Gore, Johns Hopkins _x000D_
Growth Factor-Based Differentiation: William Matsui, Johns Hopkins_x000D_
D. Stem Cell Transplantation: Richard Jones, Johns Hopkins_x000D_
E. Vaccine Development: Ivan Borrello, Johns Hopkins_x000D_
IV. Special Challenges_x000D_
A. Pediatric AML: Robert Arceci, Johns Hopkins -- pending _x000D_
B. AML in the Elderly: Richard Stone, Dana Farber _x000D_
C. Myeloproliferative Disorders: Jason Gottlib, Stanford_x000D_
D. New Clinical Trials Designs: Elihu Estey, MD Anderson_x000D_