Description
Taylor & Francis Allogeneic Immunotherapy for Malignant Diseases 2000 Edition by John Barrett, Yin-Zhen Jiang
This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors!Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more!Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines. Table of contents : - Introduction: The Graft-Versus-Leukemia EffectPaul M. SondelBiological Basis of the GVL EffectThe Immune Response to AlloantigensGraham M. Lord and Robert I. LechlerExperimental Animal Models in the Study of GVL ReactionsRobert L. Truitt, Robert Korngold, Bryon D. Johnson, Robert Townsend, and Bruce R. BlazarEffector Cells and Mechanisms of the GVL EffectYin-Zheng JiangMinor Histocompatibility Antigens in GVLTuna Mutis and Els GoulmyTissue-Specific Antigens in GVLJeffrey MolldremOncoproteins as Tumor-Specific AntigensCarlo Gambacorti-PasseriniThe GVL Effect in Clinical PracticeGVL Effects in Human Marrow Stem-Cell TransplantsJohn BarrettThe GVL Effect in Donor Lymphocyte TransfusionFrits van Rhee and Hans-Jochem KolbThe Graft-Versus-Myeloma EffectJayesh MehtaThe Graft-Versus-Tumor EffectRichard W. Childs and John BarrettAdoptive Allogeneic Cell-Mediated Immunotherapy and Nonmyeloablative Stem-Cell TransplantationShimon Slavin, Shoshana Morecki, Elizabeth Naparstek, Arnon Nagler, Gabor Varadi, Rami Ben-Yosef, and Reuven OrClinical and Basic Science Studies of Human Umbilical Cord Blood: Implications for the GVL Effect Following Cord Blood TransplantationJay Gaddy, Pierluigi Porcu, and Hal E. BroxmeyerModulation and Application of GVL EffectsSeparating GVHD and GVL ReactionsDimitrios Mavroudis and John Barrett T-Cell Subsets and Separation of GVL from GVHDSergio A. Giralt and Richard E. ChamplinMolecular Immunological Modulation of Target Cells to Enhance the GVL Effect Joachim L. Schultze and John G. GribbenGenetic Modulation of Effector Cells to Enhance GVL EffectsHelen E. Heslop and Koichi MoriwakiLeukemia-Reactive T Cells in Adoptive Immunotherapy for Relapsed Leukemia After Allogeneic TransplantationJ. H. Frederick Falkenburg and Roelof WillemzeThe BCR-ABL Oncoprotein and Immunological Targeting: Vaccination for Tumor Prevention and TherapyGeorge J. A. ten Bosch, Onno C. Leeksma, and Cornelius J.M. Melief