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Humana Press Antisense Therapeutics by M. Ian Phillips
A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.show more Part I. IntroductionAntisense Therapeutics: A Promise Waiting to be FulfilledM. Ian PhillipsAntisense Inhibition: Oligonucleotides, Ribozymes, and siRNAsY. Clare Zhang, Meghan M. Taylor, Willis K. Samson, and M. Ian PhillipsPart II. CardiovascularLocal Application of Antisense for Prevention of RestenosisPatrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, and Martin B. LeonAntisense Therapeutics for Hypertension: Targeting the Renin-Angiotensin SystemM. Ian Phillips and Birgitta KimuraAntisense Strategies for the Treatment of Heart FailureSian E. Harding, Federica del Monte, and Roger J. HajjarPart III. CancerClinical Studies of Antisense Oligonucleotides for Cancer TherapyRosanne M. Orr and F. Andrew DorrAntisense Therapy in Clinical Oncology: Preclinical and Clinical ExperiencesIngo TammRadionuclide-Peptide Nucleic Acid Diagnosis and Treatment of Pancreatic CancerEric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Weizhu Zhu, Edward R. Sauter, and Mathew L. ThakurSuppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression VectorsKazunori Aoki, Shumpei Ohnami, and Teruhiko YoshidaInduction of Tumor Cell Apoptosis and Chemosensitization by Antisense StrategiesManuel Rieber and Mary Strasberg-RieberUtility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug ResistanceTadao FunatoPart IV. Blood-Brain BarrierTransport of Antisense Across the Blood-Brain BarrierLaura B. Jaeger and William A. BanksPart V. DermalTransdermal Delivery of Antisense OligonucletoidesRhonda M. Brand and Patrick L. IversenPart VI. DrugsAntisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a ModelVikram AroraPart VII. GastrointestinalAntisense Oligonucleotide Treatment of Inflammatory Bowel DiseasesBruce R. YacyshynPart VIII. HepatitisOptimizing Electroporation Conditions for the Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry SiteRonald JubinIndex