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Humana Press Bioimaging In Neurodegeneration by Patricia A. Broderick , David N. Rahni
Bioimaging is in the forefront of medicine for the diagnosis and helps to predict the progression of AD via mild cognitive treatment of neurodegenerative disease. Conventional magnetic impairment (MCI) studies. resonance imaging (MRI) uses interactive external magnetic fields Novel neuroimaging technologies, such as neuromolecular and resonant frequencies of protons from water molecules. imaging (NMI) with a series of newly developed BRODERICK (R) However, newer sequences, such as magnetization-prepared rapid PROBE sensors, directly image neurotransmitters, precursors, acquisition gradient echo (MPRAGE), are able to seek higher and metabolites in vivo, in real time and within seconds, at separate levels of anatomic resolution by allowing more rapid temporal and selective waveform potentials. NMI, which uses an imaging. Magnetic resonance spectroscopy (MRS) images electrochemical basis for detection, enables the differentiation of metabolic changes, enabling underlying pathophysiologic neurodegenerative diseases in patients who present with mesial dysfunction in neurodegeneration to be deciphered. Neuro- versus neocortical temporal lobe epilepsy. In fact, NMI has some 1 chemicals visible with proton H MRS include N-acetyl aspartate remarkable similarities to MRI insofar as there is technological (NAA), creatine/phosphocreatine (Cr), and choline (Cho); NAA dependence on electron and proton transfer, respectively, and is considered to act as an in vivo marker for neuronal loss and/or further dependence is seen in both NMI and MRI on tissue neuronal dysfunction. By extending imaging to the study of composition such as lipids.show more Prologue: Nano- and Microimaging Surgical Anesthesia in Epilepsy PatientsI. Parkinson's DiseaseMagnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Parkinson's Disease: Structural vs Functional ChangesW. R. Wayne MartinPositron Emission Tomography and Single-Photon Emission Tomography in the Diagnosis of Parkinson's Disease: Differential Diagnosis From Parkinson-Like Degenerative DiseasesPaul D. ActonPositron Emission Tomography in Parkinson's Disease: Cerebral Activation Studies and Neurochemical and Receptor ResearchAndre R. Troiano and A. Jon Stoessl[123I]-Altropane SPECT: How It Compares to Other Positron Emission Tomography and Single-Photon Emission Tomography Dopamine Transporters in Early Parkinson's DiseaseHubert H. Fernandez, Paula D. Ravin, and Dylan P. WintPositron Emission Tomography and Embryonic Dopamine Cell Transplantation in Parkinson's DiseaseYilong Ma, Vijay Dhawan, Curt Freed, Stanley Fahn, and David EidelbergII. Alzheimer's DiseaseNeurotoxicity of the Alzheimer's b-Amyloid Peptide: Spectroscopic and Microscopic StudiesDavid R. HowlettFunctional Imaging and Psychopathological Consequences of Inflammation in Alzheimer's DementiaJan Versijpt, Rudi A. Dierckx, and Jakob KorfNeurotoxic Oxidative Metabolite of Serotonin: Possible Role in Alzheimer's DiseaseLadislav Volicer, Monika Z. Wrona, W. R. Wayne Matson, and Glenn DryhurstPredicting Progression of Alzheimer's Disease With Magnetic ResonanceKejal Kantarci and Clifford R. Jack, Jr.Stages of Brain Functional Failure in Alzheimer's Disease: In Vivo Positron Emission Tomography and Postmortem Studies Suggest Potential Initial Reversibility and Later IrreversibilityStanley I. RapoportIII. EpilepsyNeocortical Epilepsy: a-Methyl-l-Tryptophan and Positron EmissionTomography StudiesJun Natsume, Andrea Bernasconi, and Mirko DiksicPediatric Cortical Dysplasia: Positron Emission Tomography StudiesBharathi Dasan Jagadeesan, Csaba Juhasz, Diane C. Chugani, and Harry T. ChuganiBioimaging l-Tryptophan in Human Hippocampus and Neocortex: Subtyping Temporal Lobe EpilepsySteven V. Pacia and Patricia A. BroderickIn Vivo Intrinsic Optical Signal Imaging of Neocortical EpilepsySonya Bahar, Minah Suh, Ashesh Mehta, and Theodore H. SchwartzIntraoperative Magnetic Resonance Imaging in the Surgical Treatment of EpilepsyTheodore H. SchwartzPeriodic Epileptiform Discharges Associated With Increased Cerebral Blood Flow: Role of Single-Photon Emission Tomography ImagingImran I. Ali and Noor A. PirzadaImaging White Matter Signals in Epilepsy Patients: A Unique Sensor TechnologyPatricia A. Broderick and Steven V. PaciaIV. Leukodystrophy (White Matter) DiseasesOverview of the Leukoencephalopathies: An MRI Point of ViewEdwin H. KolodnyPyramidal Tract Involvement in Adult Krabbe's Disease: Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy AbnormalitiesLaura Farina, Alberto Bizzi, and Mario SavoiardoImaging Leukodystrophies: Focus on Lysosomal, Peroxisomal, and Non-Organelle PathologyAnnette O. NusbaumAdvanced Magnetic Resonance Imaging in LeukodystrophiesEdwin Y. Wang and Meng LawChildhood Mitochondrial Disorders and Other Inborn Errors of Metabolism Presenting With White Matter DiseaseAdeline Vanderver and Andrea L. GropmanMitochondrial Disease: Brain Oxidative Metabolism Studied by 31P, 1H, and 13C Magnetic Resonance Spectroscopy, Functional Magnetic Resonance Imaging, and Positron Emission TomographyGraham J. KempIndex