Description
Springer Biological Responses in Cancer Volume 1: Progress toward Potential Applications 1st Editon 2012 Softbound by Enrico Mihich
The series of volumes entitled Biological Responses in Cancer: Progress toward Potential Applications will provide information on approaches through which the interaction between neoplastic and normal cells may be modified. Each annual volume will contain contributions in areas where significant progress has been made. Topics to be dealt with include immunologic and host defense systems, control mechanisms of cell and population growth, cell differentiation, and cell transformation. The regulatory mech~sms controlling the interactions between normal and tumor cells may be immunologic in nature or they may relate to diverse biological characteristics of tumor and normal cells and their response to micro environmental factors. While the central question of tumor immunol ogy addresses the nature and uniqueness of tumor-associated antigens in humans, the identification of the stages of differentiation and functions of the various cell types involved in immunity is advancing rapidly. The de velopment of monoclonal antibody methodologies together with progress in the biochemical characterization of cell markers, cell separation, and mea surement of cell functions has significantly aided in the identification and quantitation of different cell types. Establishing the role of these cells in the regulation of human immune mechanisms offers a means for evaluating the status of the immune responses in cancer patients and for assessing the effects tumor and antitumor treatments may exert on their functionality, which, in turn, may alter the effects of antitumor treatments. 1 Cell-Surface Antigens in Acute Leukemia.- 1. Introduction.- 2. Methods of Identification of Leukemia-Associated Membrane Antigens.- 3. Acute Lymphoblastic Leukemia-Associated Membrane Antigens.- 4. Acute Myeloblastic Leukemia-Associated Membrane Antigens.- References.- 2 Suppressor Cells in Tumor-Host Interactions.- 1. Introduction.- 2. Immunoregulation and Suppressor T Cells.- 3. The Tumor-Bearing Host.- 4. Suppressor Mechanisms in Tumor-Bearing Hosts.- 5. Suppressor Cells in Human Cancer.- 6. Conclusions.- References.- 3 The Interleukins: Regulation of Lymphocyte Differentiation, Proliferation, and Functional Activation.- 1. Introduction.- 2. The Interleukins.- 3. Interleukin 1.- 4. Interleukin 2.- 5. Interplay of Interleukins and Other Lymphokines.- 6. Therapeutic Potential of the Interleukins.- References.- 4 The Interaction of Human T-Cell Growth Factor with Normal and Neoplastic T Cells.- 1. Introduction.- 2. Purification and Biochemical Characterization of Human TCGF.- 3. Culture Conditions for Generation of Human TCGF.- 4. Relationship between TCGF and Other Lymphokines.- 5. Development and Maintenance of Functional T-Cell Clones.- 6. Interaction of TCGF with Neoplastic T Cells.- 7. Isolation of a New Class Type-C Retrovirus from Human T Cells.- 8. Concluding Remarks: The Functional Implications of TCGF.- References.- 5 Interferons: Biological Response Modification and Pharmacology.- 1. Introduction.- 2. The Interferon System.- 3. Factors Influencing Cellular Activity.- 4 Immunomodulation.- 5. Enzymatic Alterations.- 6. Clinical Pharmacology.- 7. Conclusion.- References.- 6 Role of Thymosin and Other Thymic Hormones in T-Cell Differentiation.- 1. Introduction.- 2. Biochemical Characteristics of Thymosin.- 3. Biological Effects of Thymosin and Other Thymic Factors in Experimental Animal Models.- 4. Biological Effects of Thymosin and Other Thymic Factors in Man.- 5. Concluding Remarks.- References.- 7 Host Factors Influencing the Growth and Spread of Tumors.- 1. Introduction.- 2. Regional Differences in Tumor Growth.- 3. Regional Differences in Normal Tissue Growth and Function.- 4. Host Factors Involved in Vascularization of Tumors.- 5. Inductive Tissue Interactions.- 6. Host Factors in Tumor Cell Seeding and Development.- 7. Other Host Factors Influencing Tumor Growth.- 8. General Comments.- References.- 8 The Biological Diversity of Malignant Neoplasms.- 1. Introduction.- 2. Biological Diversity of Metastatic Neoplasms.- 3. The Development and Progression of Metastasis.- 4. Implications of Phenotypic Diversity for Experimental Studies: Propagation of Heterogeneous Tumors Used to Evaluate Therapeutic Agents.- 5. Phenotypic Diversity of Neoplasms and the Challenge for Therapy.- 6. Circumvention of the Problem of Cellular Diversity.- 7. Concluding Remarks.- References.