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Humana Press Bone Metastasis by Gurmit Singh , Shafaat A. Rabbani
A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.show more Part I. Fundamental ConceptsOverviewSadmeet Singh and Gurmit SinghParathyroid Hormone-Related Peptide and MalignancyDavid GoltzmanVitamin D and Vitamin D Analogs in Cancer Progression and MetastasisRichard Kremer and Shafaat A. RabbaniRole of TGF-b and IGF in Tumor Progression and Bone MetastasesErin Giles and Gurmit SinghBiologic and Therapeutic Implications of Osteomimicry and Epithelial-Mesenchymal Transition in Prostate CancerWen-Chin Huang, Valerie Odero-Marah, and Leland W. K. ChungRoles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and MetastasisKristina A. Szabo and Gurmit SinghContribution of Osteopontin to the Development of Bone MetastasisAlison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, and Ann F. ChambersRole of Interleukin-11 in Osteolytic Bone MetastasisRyan R. Simon, Martin K. Butcher, and Stephen G. ShaughnessyCell Adhesion Molecules in Tumor MetastasisSujata Persad and Gurmit SinghPTHrP and Cancer: Prostate and LungLeonard J. Deftos, D. W. Burton, and Randolph H. HastingsAntithrombotics in Tumor Growth and MetastasisShaker A. MousaPart II. Therapeutic StrategiesChallenges and Strategies in the Analysis of Multiple Events in OncologyPierre P. Major and Richard J. CookIntegrins: Novel Targets for the Treatment of Bone MetastasisGraham C. Parry, Fernando Donate, Marian L. Plunkett, David E. Shaw, Steven Pirie-Shepherd, and Andrew P. MazarBone Metastasis and Pathological Fractures: Bone Tissue Engineering as a Novel TherapyLaurie A. McDuffee, Nigel Colterjohn, and Gurmit SinghRole of Photodynamic Therapy for Bone MetastasisShane Burch and Albert J. M. YeeDocetaxel for Metastatic Cancer and Its Rolein Combination Therapies for Advanced Prostate CancerEllen K. Wasan, Martin Gleave, Karen Fang, Kim Chi, Gwyn Bebb, Lincoln Edwards, and Marcel B. BallyUse of Tetracyclines for Bone MetastasesEric Seidlitz, Zeina Saikali, and Gurmit SinghRole of Bisphosphonates in Skeletal MetastasesArif Hussain and Fred SaadRadiation Treatment of Bone MetastasesEdward Chow, Jackson Wu, and Elizabeth Toni BarnesIndex