Description
Springer Cell Adhesion Molecules Cellular Recognition Mechanisms 1st Editon 2013 Softbound by Martin E. Hemler, Enrico Mihich
The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression. Transcriptional Regulation of the ?II? Integrin Gene.- Integrin Expression and Epithelial Cell Differentiation.- Fibronectin Mutations in Mice.- General Discussion Session I.- Regulation of ?1 Integrin-Mediated Adhesive Functions.- Elements for a Structural/Functional Model of Human Platelet Plasma Membrane Fibrinogen Receptor, the Glycoprotein Ilb/IIIa Complex (Integrin ?IIb/?3).- Extracellular and Intracellular Functions of VLA Proteins.- Signal Transduction from Leukocyte Integrins.- Coordinate Role for Proteoglycans and Integrins in Cell Adhesion.- Adhesion Molecules at Endothelial Cell to Cell Junctions.- Regulation of T Cell Adhesion with T Cell Differentiation and with Acute Activation by MIP-1? Cytokine Immobilized on CD44 Proteoglycan.- Activation of LFA-1: The L16 Epitope Is a Cation-Binding Reporter.- Activation-Dependent Regulation of ?1 Integrin Expression and Function in Human Natural Killer Cells.- Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma: Role of Adhesion Molecules and ?1 Integrins.- Tumor Cell-Endothelial Cell Interactions during Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules.- Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis.- CD44 and Splice Variants of CD44 in Normal Differentiation and Tumor Progression.