Description
Humana Press Chemosensitivity Volume Ii In Vivo Models Imaging And Molecular Regulators by Rosalyn D. Blumenthal
A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.show more Part I. Measurements of DNA Damage, Cell Death, and Regulators of CytotoxicityIn Vitro Micronucleus Technique to Predict ChemosensitivityMichael FenechCell Cycle and Drug SensitivityAslamuzzaman Kazi and Q. Ping DouTUNEL Assay as a Measure of Chemotherapy-Induced ApoptosisRobert WiederApoptosis Assessment by the DNA Diffusion AssayNarendra P. SinghPARP Cleavage and Caspase Activity to Assess ChemosensitivityAlok C. Bharti, Yasunari Takada, and Bharat B. AggarwalDiphenylamine Assay of DNA Fragmentation for Chemosensitivity TestingCicek Gercel-TaylorImmunodetecting Members of the Bcl-2 Family of ProteinsRichard B. Lock and Kathleen M. MurphyCorrelation of Telomerase Activity and Telomere Length to ChemosensitivityYasuhiko KiyozukaApplication of Silicon Sensor Technologies to Tumor Tissue In Vitro: Detection of Metabolic Correlates of ChemosensitivityPedro Mestres-Ventura, Andrea Morguet, Anette Schofer, Michael Laue, and Werner SchmidtOverview of Tumor Cell Chemoresistance MechanismsLaura Gatti and Franco ZuninoFlow Cytometric Monitoring of Fluorescent Drug Retention and EffluxAwtar Krishan and Ronald M. HamelikFlow Cytometric Measurement of Functional and Phenotypic P-GlycoproteinMonica Pallis and Emma Das-GuptaMeasurement of Ceramide and Sphingolipid Metabolism in Tumors: Potential Modulation of ChemosensitivityDavid E. ModrakPart II. Genomics, Proteomics, and ChemosensitivityGene Expression Profiling to Characterize Anticancer Drug SensitivityJames K. Breaux and Gerrit LosIdentifying Genes Related to Chemosensitivity Using Support Vector MachineLei BaoGenetic Manipulation of Yeast to Identify Genes Involved in Regulation of ChemosensitivityGiovanni L. Beretta and Paola PeregoReal-Time RT-PCR (Taqman (R)) of Tumor mRNA to Predict Sensitivity of Specimens to 5-FluorouracilTetsuro KubotaUse of Proteomics to Study ChemosensitivityJulia Poland, Silke Wandschneider, Andrea Urbani, Sergio Bernardini, Giorgio Federici, and Pranav SinhaPart III. In Vivo Animal Modeling of ChemosensitivityClinically Relevant Metastatic Breast Cancer Models to Study ChemosensitivityLee Su Kim and Janet E. PriceOrthotopic Metastatic (MetaMouse (R)) Models for Discovery and Development of Novel ChemotherapyRobert M. HoffmanPreclinical Testing of Antileukemic Drugs Using an In Vivo Model of Systemic DiseaseRichard B. Lock, Natalia L. Liem, and Rachael A. PapaAssessing Growth and Response to Therapy in Murine Tumor ModelsC. Patrick Reynolds, Bee-Chun Sun, Yves A. DeClerck, and Rex A. MoatsEvaluation of Chemosensitivity of Micrometastatses with Green Fluorescent Protein Gene-Tagged Tumor Models in MiceHayao Nakanishi, Seiji Ito, Yoshinari Mochizuki, and Masae Tatematsu99mTc-Annexin A5 Uptake and Imaging to Monitor ChemosensitivityTarik Z. Belhocine and Francis G. BlankenbergMagnetic Resonance Imaging of Tumor Response to ChemotherapyRichard Mazurchuk and Joseph A. SpernyakMetabolic Monitoring of Chemosensitivity with 18FDG PETGuy Jerusalem and Tarik Z. BelhocineIndex