Description
Elsevier Chimeric Antigen Receptor T-Cell Therapies for Cancer A Practical Guide 1st Edition by Lee, Daniel
Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells from patient referral to post-therapy management in a concise and practical format. Providing clinical guidance on the implementation and management of CAR T-cell therapy, this clinical resource keeps you up-to-date on the latest developments in this rapidly evolving area.Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care.Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon.Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy. Introduction 1. When to Refer a Patient for CAR-T Cell Therapy 2. Optimizing the Apheresis Product 3. CAR T Cells: Cell Processing Laboratory Considerations 4. Peri-CAR-T Cell Management 5. Management of Cytokine Release Syndrome 6. Special Considerations for ICU Management of Patients Receiving CAR Therapy 7. Neurotoxicities After CAR-T Cell Immunotherapy 8. Hematologic and Non-CRS Toxicities 9. Response Assessment and PosteCAR-T Cell Therapy Management 10. Relapse Management and Role for Consolidative Hematopoietic Stem Cell Transplantation Following CAR-T Cell Therapy 11. Promising Chimeric Antigen Receptors for Non-B Cell Hematological Malignancies, Pediatric Solid Tumors, and Carcinomas 12. CAR T Cell Therapy for CNS Malignancies 13. CAR 2.0: The Next Generation of Synthetic ReceptoreBased Cellular Therapy for Cancer