Description
Taylor & Francis Clinical Immunotoxicology 1992 Edition by David S Newcombe
This text is a comprehensive source of information on the toxic effects of environmental, industrial, and pharmacological agents on the human immune system. Focusing entirely on human immunotoxicology, without relying on animal models, the book explains the basic principles of immunotoxicology defines the mechanisms by which immunotoxins act, describes the clinical expression of immunotoxic disorders in the lung, skin, and other target organs, offers practical guidelines for early detection and control of host defense dysfunctions, and explores strategies for assessing the short- and long-term health effects of new and old chemicals and biologicals. The book includes extensive discussions on the role of low-dose, chronic immunosuppression in cancer, as well as on specific environmental and occupational immunotoxins and immunotoxic drugs used in hematology, anesthesiology, oncology and transplantation surgery. Table of contents : - Part 1 Basic principles of immunotoxicology: immunotoxicology - a new challenge, David S. Newcombe; the immunological assessment of innumotoxic effect in man, Noel R. Rose and Joseph B. Margolick; the immune system - an appropriate and specific target for chemicals, David S. Newcombe; flow cytometric analysis of the immune and phagocytic cells, Peter A. Ward; an approach for analyzing the role of mast cells in immunotoxicologic processes and other biological responses, Barry K. Wershil and Stephen J. Galli. Part 2 Models of immunotoxic mechanisms: toxicity of monoclonal antibodies and conjugates, Ira Berkower; the immunotoxicology of cytokines, Roger B. Cohen et al; immunopathogenesis of the acquired immune deficiency syndrome - relevance to immunotoxicity, Joseph P. Margolick. Part 3 Immunotoxic drugs: cyclosporine - lessons from a useful immunosuppressant, Ahmed H. Esa and Allan D. Hess; drug-induced immunologic disorders of the blood, Kent Holland and Jerry L. Spivak; halothane hepatitis - mechanisms of immunotoxicity, Jackie L. Martin; selective interactions of cancer chemotherapeutic agents with the host immune system, Wafik S. El-Deiry. Part 4 Immunologic disorders of the lung: pulmonary hypersensitivity disorders, I. Leonard Bernstein; the immunopathogenesis of pulmonary responses to environmental and chemical pollutants, David S. Newcombe; bronchoalveolar lavage and bronchial reactivity in humans associated with environmental and chemical exposures, David S. Newcombe and Peter B. Terry. Part 5 Environmental and occupational immunotoxins: recent studies of the human immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, Richard E. Hoffman et al; immunotoxicity of organophosphorous compounds, David S. Newcombe and Ahmed H. Esa; environmental chemicals with immunotoxic properties, Ali M. Saboori and David S. Newcombe; metal-induced alterations of immunity, Michael Kowolenko et al; the immunology of contact dermatitis, Kristian Thestrup-Pedersen et al.