Description
Springer Current Approaches to Therapy 1st Editon 2012 Softbound by William McGuire
The enormous impact of both clinical and basic research on the field of breast cancer can now be readily appreciated. It is the purpose of this new series of books to bring together the recent major advances in our understanding of the disease. The first volume is devoted exclusively to treatment. It is written by scholars who are actually investigating the biological principles which underlie our current approaches to therapy. For example, countless articles have appeared proposing some ad vantage for one surgical approach to primary breast cancer compared with another. The new message is that these arguments for the superior ity of one surgical approach over a.nother are valid only in that minority of patients whose disease is absolutely confined to the primary tumor site. It is far less important which surgical approach is selected for the larger group of patients who present with occult distant metastases. The whole subject of adjuvant therapy is still in its infancy. We have progressed from single-agent adjuvant chemotherapy to combined modality regimens consisting of combination chemotherapy plus im munotherapy, plus radiotherapy, plus endocrine therapy. It will un doubtedly take many years to sort out the proper use of these agents. 1. Surgery of Primary Breast Cancer.- 1. Principles of Breast Cancer Surgery: From Halsted to the Present.- 2. Factors Prompting Redefinition of the Basis for Breast Cancer Surgery.- 3. A Biologic Basis for Cancer Surgery.- 4. An Overview of Presently Employed Operations.- 5. Considerations Regarding Special Surgical Problems.- 6. Surgery in Conjunction with Other Therapeutic Modalities.- 7. Comments and Prospects for the Future.- 8. References.- 2. Pathology of Breast Cancer.- 1. Introduction.- 2. Histologic Types of Breast Cancer.- 3. Histologic Grading.- 4. Nuclear Grading.- 5. Circumscription.- 6. Tumor Size.- 7. Cell Reaction.- 8. Stromal Change.- 9. Elastica.- 10. Mucin.- 11. Calcium.- 12. Glycogen.- 13. Squamous Metaplasia.- 14. Apocrine Change, Oxyphilia.- 15. Necrosis.- 16. Relationship of Fibrocystic Disease to Cancer.- 17. Noninvasive Cancer in the Vicinity of the Dominant Tumor.- 18. Lymphatic Invasion.- 19. Blood Vessel Invasion.- 20. Perineural Space Invasion.- 21. Multicentric Cancer and Changes in Quadrants Remote from the Primary Tumor.- 22. Nipple Involvement.- 23. Relationship of Florid Papillomatosis of the Nipple to Cancer.- 24. Involvement of Skin over the Tumor.- 25. Alterations of Regional Lymph Nodes in Breast Cancer.- 26. Multiple Cancers (Dominant Masses) in the Same Breast.- 27. References.- 3. Systemic Adjuvant (Combined Modality) Therapy in the Treatment of Primary Breast Cancer.- 1. Introduction.- 2. Tumor Cell Kinetics and Adjuvant Chemotherapy.- 3. Surgical Adjuvant Therapy in Animal Model Systems.- 4. Early Trials of Systemic Adjuvant Therapy.- 5. Recent and Present Trials of Systemic Adjuvant Therapy.- 6. Comments and Speculations.- 7. References.- 4. Combination Chemotherapy for Advanced Disease.- 1. Introduction.- 2. Experimental Background of Chemotherapy of Breast Cancer.- 3. Pharmacology.- 4. Clinical Evaluation of Drugs.- 5. Combinations.- 6. Chemotherapy and Hormonal Therapy.- 7. Immunotherapy.- 8. The Changing Role of Chemotherapy in Breast Cancer Treatment.- 9. Special Problems.- 10. The Future of Chemotherapy.- 5. Physiological Principles Underlying Endocrine Therapy of Breast Cancer.- 1. Introduction.- 2. Prolactin.- 3. Estrogen.- 4. Progesterone.- 5. Glucocorticoids.- 6. Androgens.- 7. Conclusions.- 8. References.- 6. The Changing Role of Radiation Therapy in Breast Cancer: A Study in Therapeutic Controversy.- 1. Introduction.- 2. Stage I.- 3. Stage II.- 4. Stage III.- 5. Stage IV.- 6. Conclusions.- 7. References.- 7. Immunology and Immunotherapy of Human Breast Cancer: Recent Developments and Prospects for the Future.- 1. Introduction.- 2. Histologic Evidence for Host Immune Response.- 3. General Immune Competence.- 4. Tumor-Associated Antigens.- 5. Immunological Evidence for Viral Antigens in Human Breast Cancer.- 6. Effect of Hormones on Immunity.- 7. Influence of Radiotherapy on the Immune Response.- 8. Immunotherapy.- 9. Immunoprophylaxis of Breast Cancer: Outlook for the Future.- 10. Conclusions and Prospects.- 11. References.