Description
SPRINGER Drug Metabolism Current Concepts by IONESCU CORINA
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design. Drug Metabolism In Context: Introduction.- Absorption.- Drug Distribution.- Dynamics Of Drug Action.- 5 Drug Clearance.- Dynamics Of Drug Clearance.- Pathways Of Biotransformation - Phase I Reactions: Introduction.- Phase I And Phase II Metabolism: General Considerations.- Oxidations Involving The Microsomal Mixed-Function Oxidase System.- Oxidations Involving Other Enzymatic Systems.- Metabolic Reactions Involving Reduction.- Hydrolysis.- Miscellanous Phase I Reactions.- The Fate Of Phase I Reaction Products.- Pathways Of Biotransformation - Phase II Reactions: Introduction.- Glucuronidation.- Acetylation.- Glutathione Conjugation.- Other Conjugative Reactions.- Concluding Remarks.- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction.- Interaction Between A Drug Substrate And An Enzyme.- Enzyme Systems With Specific Roles.- Final Remarks.- Induction And Inhibition Of Drug-Metabolising Enzymes.- Introduction.- Induction.- Inhibition.- Consequences Of The Above Phenomena.- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition.- Factors That Influence Drug Biotransformation.- Introduction.- Intrinsic Factors.- Environmental Factors.- Further Observations.- Impact Of Gene Variability On Drug Metabolism.- Introduction.- Basic Principles Of Pharmacogenetics.- Pharmaco-Informatics.- Implications For Third Millennium Medicine.- Drug Interactions And Adverse Reactions: Introduction.- Drug-Drug Interactions.- Interactions Between Drugs And Other Entities.- Adverse Reactions.- Summary.- Strategies For Drug Design.- Introduction.- Pharmacokinetics And Metabolism In Drug Research.- The Role Of Formulation.- Concluding Remarks.- Index.