Description
Springer Enzyme Kinetics In Drug Metabolism Fundamentals And Applications 2Ed (HB) by Nagar S.
This second edition further develops the principles of applying kinetic principles to drug metabolizing enzymes and transporters. Chapters are divided into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting specific oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for drug metabolizing enzymes and transporters, understanding of variability both experimental and interindividual (pharmacogenomic), and expanded case studies that provide real life examples of applying these principles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, in some cases step-by-step instructions with readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and fully updated, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition serves as a practical teaching tool for novice and advanced scientists interested in the fundamental concepts. Table of Contents:- PART I: UNDERLYING PRINCIPLES OF ENZYME KINETICS1. Fundamentals of Enzyme Kinetics - Michaelis-Menten and Non-Michaelis Type (Atypical) Enzyme KineticsEleanore Seibert and Timothy S. Tracy2. Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical SignificanceBarbara Ring, Steven A. Wrighton, and Michael Mohutsky3. Irreversible Enzyme Inhibition Kinetics and Drug-Drug InteractionsMichael Mohutsky and Stephen D. Hall4. Multi-enzyme Kinetics and Sequential MetabolismLarry C. Wienkers and Brooke Rock5. Consideration of the Unbound Drug Concentration in Enzyme KineticsNigel J Waters, R Scott Obach, and Li Di6. Numerical Methods for Modeling Enzyme KineticsJaydeep Yadav, Ken Korzekwa, and Swati NagarPart II: Crystal Structure, Biochemistry, and Impact On Enzyme Kinetics7. Crystal Structures of Drug-Metabolizing CYPsD. Fernando Estrada, Amit Kumar, Christopher S. Campomizzi, and Natalie Jay8. The Structure and Mechanism of Drug TransportersArthur G. RobertsPART III: KINETICS OF DRUG METABOLIZING ENZYMES AND TRANSPORTERS9. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450Ken Korzekwa10. Enzyme Kinetics, Pharmacokinetics, and Inhibition of Aldehyde oxidaseErickson M. Paragas, Kanika Choughule, Jeffrey P. Jones, and John T. Barr11. Enzyme Kinetics of PAPS-sulfotransferaseMargaret O. James12. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)Jin Zhou, Upendra Argikar, and John O. Miners13. Principles and Experimental Considerations for In Vitro Transporter Interaction AssaysSid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica Weiskircher-Hildebrandt, Venkata Mukkavilli, and Ismael J. HidalPART IV: MODELING CONSIDERATIONS14. Prediction of Drug Clearance from Enzyme and Transporter KineticsPriyanka R. Kulkarni, Amir S. Youssef, and Aneesh A. Argikar15. Systems Biology Approaches to Enzyme KineticsNnenna A. Finn, Andrew D. Raddatz, and Melissa L. KempPART V: APPLICATION TO THE CLINIC AND REGULATORY CONSIDERATIONS16. Variability in Human In Vitro Enzyme KineticsChristopher R. Gibson, Ying-Hong Wang, Ninad Varkhede, and Bennett Ma17. Sources of Interindividual VariabilityYvonne S. Lin,Kenneth E. Thummel, Brice D. Thompson, Rheem A. Totah, and Christi W. Cho18. Ontogeny of Drug Metabolizing EnzymesAarzoo Thakur, Md Masud Parvez, J. Steven Leeder, and Bhagwat Prasad19. How Science is Driving Regulatory GuidancesXinning Yang, Jianghong Fan, and Lei ZhangPART VI: CASE STUDIES 20. Case Study 1: Practical Considerations with Experimental Design and InterpretationJohn T Barr and Otito Iwuchukwu21. Case Study # 2: Practical Analytical Considerations for Conducting In Vitro Enzyme Kinetic StudiesUpendra A. Argikar and Swati Nagar22. Case Study 3: Criticality of High-Quality Curve Fitting: Getting a Km,app isn't as Simple as it May SeemDavid M. Stresser and Arian Emami-Riedmaier23. Case Study 4 Application of Basic Enzyme Kinetics To Metabolism Studies - Real Life ExamplesYongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald Tweedie24. Case Study 5. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by MontelukastKen Korzekwa25 Case Study 6: Deconvoluting Hyperbilirubinemia: Differentiating between Hepatotoxicity and Reversible Inhibition of UGT1A1, MRP2 or OATP1B1 in Drug DevelopmentIan Templeton, Gary Eichenbaum, Rucha Sane, Jin Zhou26. Case Study 7. Transporters Case Studies: In Vitro Solutions for Translatable Outcomes Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica Weiskircher-Hildebrandt, Venkata Mukkavilli, and Ismael J. Hidalgo27. Case Study 8: Status of the Structural Mass Action Kinetic Model of P-gp Mediated Transport through Confluent Cell Monolayers Joe Bentz and Harma Ellens28. Case Study 9: Probe-Dependent Binding Explains Lack of CYP2C9 Inactivation by 1-Aminobenzotriazole (ABT)Jasleen K. Sodhi and Jason S. Halladay29. Case Study 10: A Case to Investigate Acetyl Transferase KineticsJennifer L Dumouchel and Valerie M Kramlinger30. Case Study 11. Considerations for Enzyme Mapping Experiments: Interaction between the Aldehyde Oxidase Inhibitor Hydralazine and GlutathioneRachel D. Crouch, Jessica L. Beers, and Klarissa D. Jackson231. Case Study 12: Roadmap to Quantifying Ago2-Mediated siRNA Metabolic Activation Kinetics Sara C. Humphreys, Babak Basiri, Armina Abbasi and Brooke M. Rockshow more