Description
Cengage GENETICS THE CONTINUITY OF LIFE W INFOTRAC 1999 Edition by Daniel Fairbanks, W. Ralph Andersen
For quite some time textbooks have steered the teaching of genetics down a fairly narrow path - transmissions genetics first, followed by molecular genetics. In Genetics: The Continuity of Life, Fairbanks and Andersen modernize the study of genetics for students. With a clear, robust style, the authors approach genetics at its most fundamental molecular level, building on students' previous exposure from other courses. Once the molecular concepts are in place, transmission genetics is more easily understood.The result is a textbook that reflects the way geneticists think about solving genetics problems in a completely integrative manner. Students relate to the organization and are able to grasp the larger concepts and their applications. Table of contents :- 1. INTRODUCTIONGenetics in Human Society / The Universality of Genetic Principles / Model Organisms / Organizing the Study of Genetics / The Concept of the Gene / Genetic AnalysisPART I: MOLECULAR FOUNDATIONS OF GENETICS2. DNA STRUCTURE AND REPLICATIONThe Genetic Material / Nucleic Acid Structure / Semiconservative DNA Replication / The Process of DNA Replication / Replication of Entire DNA Molecules3. TRANSCRIPTION AND RNA PROCESSINGThe Central Dogma / Overview of Transcription and RNA Processing in Prokaryotes and Eukaryotes / Initiation of Transcription / Elongation / Termination / Transcription of rRNAs and tRNAs / mRNA Processing / Processing of rRNAs and tRNAs4. TRANSLATION AND PROTEIN FUNCTIONAmino Acids and Polypeptides / The Genetic Code / Ribosomes, the Sites of Translation / The Role of tRNA / Deciphering the Genetic Code / Initiation of Translation / Elongation / Termination / Protein Structure and Function5. MUTATIONTypes of Mutations / Spontaneous Mutation / Induced Mutations / DNA Repair Mechanisms6. AN INTEGRATED VIEW OF GENE EXPRESSIONThe Anatomy of a Gene and Its Expression / The Human ss-Globin Gene / Enzymes, Biochemical Pathways, and MutationPART II: GENETICS OF CELLS7. BACTERIAL GENETICSBacterial Culture / Structure of Bacterial Chromosomes / DNA Transfer and Recombination / Transformation / Conjugation / Phage Life Cycles / Transduction / Genome Sequencing8. REGULATION OF GENE EXPRESSIONThe lac Operon / Mutations in the lac Operon / The trp Operon / Regulation of Lysis and Lysogeny / Transcriptional Gene Regulation in the Eukaryotes / Gene Regulation Beyond Transcription9. RECOMBINANT DNA AND MOLECULAR ANALYSISRecombinant DNA / Plasmid Cloning Vectors / Vectors for Cloning Large DNA Inserts / Cloning Strategies / Expression Vectors / The Polymerase Chain Reaction (PCR) / Gel Electrophoresis / DNA, RNA and Protein Blotting / DNA Sequencing10. EUKARYOTIC GENOME ORGANIZATIONRepetitive and Nonrepetitive DNA / Eukaryotic DNA Packaging / The Eukaryotic Chromosome / Gene Organization in Chromosomes / Whole Genome Organization11. MITOSIS, MEIOSIS, AND LIFE CYCLESThe Cell Cycle and Mitosis / Meiosis / A Closer Look at Prophase I / Life CyclesPART III: GENETICS AND ORGANISMS12. MENDELIAN GENETICSMendel''''s Experiments / The Molecular Basis of Dominance / The Cellular Basis for Segregation / The Cellular Basis of Independent Assortment / Mendelian Inheritance in Humans / Mendelian Genetics and Probability / About Mendel13. VARIATIONS ON MENDEL''''S THEMEMultiple Alleles and Dominance Relations / Epistasis / Penetrance and Expressivity / DNA Markers in Genetic Analysis14. SEX DETERMINATION AND SEX-RELATED INHERITANCEPromotion of Cross-Fertilization / Sex Determination / Heteromorphic Chromosomes and Sex Determination / Sex-Linked Inheritance / Dosage Compensation / Sex-Influenced and Sex-Limited Traits15. CHROMOSOME MAPPINGThe Discovery of Linkage and Crossing-Over / Two-Factor Linkage Analysis / Map Distance Correction / Three-Factor Linkage Analysis / Multifactor Chromosome Mapping / Genetic Mapping in Humans / Physical Chromosome Mapping / Practical Applications of Chromosome Mapping16. GENETIC FINE STRUCTURETetrad Analysis / Unordered Tetrad Analysis / Gene Conversion and the Mechanism of Crossing-Over / Intragenic Recombination / Complementation / Fine-Structure Mapping / Mitotic Crossing-Over17. ALTERATIONS IN CHROMOSOME NUMBER AND STRUCTUREAneuploidy / Polyploidy / Alterations of Chromosome Structure / Chromosome Alterations in Humans18. EXTRANUCLEAR INHERITANCEThe Origins and Cellular Functions of Mitochondria and Plastids / Organellar Genomes / Mitochondrial Inheritance / Mitochondrial DNA and Genetic Disorders in Humans / Plastid Inheritance / Other Types of Extranuclear Inheritance / Correctly Recognizing Extranuclear InheritancePART IV: GENETICS OF POPULATIONS19. POPULATION GENETICSHardy-Weinberg Equilibrium / Genetic Change in Populations / Mutation / Migration / Non-Random Mating / Selection / Random Genetic Drift20. QUANTITATIVE GENETICSStatistical Descriptions of Metric Characters / Additive Gene Action and Continuous Variation / Heterosis and Inbreeding / Depression / Environmental Variation / Broad-Sense Heritability / Narrow-Sense Heritability and Selection / Limits on Selection21. EVOLUTIONARY GENETICSSpeciation / Molecular Evolution / Maintenance of Genetic Diversity / Phylogenetic AnalysisPART V: GENE EXPRESSION AND THE ORGANISM22. TRANSPOSABLE ELEMENTSEukaryotic Transposons / Retrotransposons and Retroposons / Prokaryotic Transposons / Using Transposable Elements in Research23. DEVELOPMENTAL GENETICSDifferentiation and Totipotency / Genetic Control of Development in Caenorhabditis elegans / Genetic Control of Development in Drosophila melanogaster / Comparison of Mammalian and Drosophila Development Genetics / Plant Developmental Genetics / Comparison of Plant and Animal Developmental Genetics24. GENES AND CANCERGenetic Control of the Cell Cycle / The Molecular Basis of Cancer / Examples of Genes That Influence Cancer / The Etiology of Cancer / Cancer Prevention, Detection, and Treatment25. GENES AND IMMUNITYImmune Responses / Antibody Structure / Antibody Genes / Cell-Mediated Immunity Genes / Immune System Malfunction / Antibodies as Tools in Genetic ResearchPART VI: APPLICATIONS OF GENETICS26. GENETICS IN MEDICINE AND FORENSICSThe Human Genome Initiative / Genetic Testing / DNA Fingerprinting / Genetic Pharmacology / Human Gene Therapy / Clinical Genetics27. GENETICS IN AGRICULTURE AND INDUSTRYGenetic Diversity / Plant Breeding / Plant Biotechnology / Animal Breeding and Biotechnology / Applications of Genetics in Industry28. LEGAL AND ETHICAL ISSUES IN GENETICSEugenics / Genetic Testing and Screening / Legal Protection and Intellectual Property Rights in Genetics / Recombinant DNA and Safety / Genetics and Science Education / SOLUTIONS TO SELECTED PROBLEMS / GLOSSARY / INDEX