Description
Springer Hyperthermia and Cancer 1st Editon 2012 Softbound by George M. Hahn
Hyperthermia as a tool for the treatment of malignant disease is rapidly becoming a clinical reality. In this book I am attempting to summarize the known biological and physical underpinnings that have led to this development. I also present a compilation of existing clinical results, limited as these are. My aim is to provide oncologists and other physicians with up-to-date information on this modality, which is both new and old, as well as to make available to biologists, physicists and engineers sum maries of currently available information on specific areas of hyperthermic research. Many people have helped me with this book. Specifically, thanks are due to Drs. William Dewey, Jean Dutreix, Peter Fessenden, Gloria Li, and Jane Marmor. Their suggestions have been invaluable. I hope that not too many errors and omissions have crept into the volume, but in any case, for these I have only myself to blame. I also wish to express my appreciation to David Betten and Marie Graham for their help. Most of this material was written while I was on sabbatical leave on the shores of Lake Atitlan in Guatemala. There I enjoyed the hospitality of a gracious, friendly, and proud people who deserve better than fate seems to have in store for them. 1. Introduction: Historical and General Comments.- 2. Mammalian Cell Survival Responses after Exposure to Elevated Temperatures.- 2.1. Introduction.- 2.2. Heat Sensitivity of Mammalian Cells: Definition.- 2.3. Assays.- 2.4. Survival of Cells Exposed to Single Heat Treatments.- 2.5. Modifications of Heat Responses.- 2.6. Survival of Cells Exposed to Multiple Heat Treatments.- 2.7. Summation.- 3. Thermal Enhancement of the Actions of Anticancer Agents.- 3.1. Introduction.- 3.2. Thermal Enhancement of Radiation Sensitivity.- 3.3. Enhancement by Hyperthermia of Drug Cytotoxicity.- 3.4. Summary.- 4. Mechanisms of Heat Action.- 4.1. Introduction.- 4.2. Heat Death of Cells.- 4.3. Heat-Enhanced X-Ray Cytotoxicity.- 4.4. Drug Cytotoxicities at Elevated Temperatures.- 4.5. Summary.- 5. Responses of Murine Tumors and Normal Tissues.- 5.1. Introduction.- 5.2. Responses of Murine Tumors to Hyperthermia Alone.- 5.3. Normal Tissue Responses to Heat.- 5.4. Responses of Tumor and Normal Tissue to Combinations of Heat and X-Ray.- 5.5. Responses of Tumors to Combinations of Heat and Drugs.- 5.6. Do Tumor Cells Die in the Same Manner In Vivo as They Do In Vitro?.- 5.7. Summary.- 6. Technical Aspects of Hyperthermia.- 6.1. Introduction.- 6.2. Localized Heating.- 6.3. Regional Heating.- 6.4. Whole-Body Heating.- 6.5. Possible Adverse Aspects of Heating.- 6.6. Measurement of Temperatures.- 6.7. Summary.- 7. Effects of Hyperthermia Against Spontaneous Cancers.- 7.1. Introduction.- 7.2. Historical Background.- 7.3. Cancers in Out-Bred Animal Populations.- 7.4. Human Cancers: Heat Alone.- 7.5. Human Cancer: Heat Plus Irradiation.- 7.6. Human Cancers: Heat Plus Drugs.- 7.7. Conclusion.- 7.8. Summary.- References.