Description
LAP LAMBERT Academic Publishing Immunogenetika Tuberkuleza 2013 Edition by Kaluzhenina Anna Andreevna
Tuberkulez ostaetsya ser'eznym infektsionnym zabolevaniem, s vysokoy smertnost'yu, privodya k 3 millionam smertey ezhegodno, priblizitel'no pyat' smertey v minutu. Okolo 8-10 millionov zarazhayutsya etim boleznetvornym mikroorganizmom kazhdyy god. Chastota ustoychivosti k razlichnym preparatam izmenyaetsya geograficheski, i priobretennaya (vtorichnaya) ustoychivost' bol'she rasprostranenna, chem pervichnaya. MLU shtammy mogut voznikat' kak sledstvie posledovatel'nogo nakopleniya mutatsiy k odinochnym preparatam ili odnostupenchatyy protsess, takoy kak priobretenie elementa MLU, ili mutatsiya, kotoraya izmenyaet (naprimer), strukturu kletochnoy stenki. Vse imeyushcheesya dokazatel'stva ukazyvayut na to, chto prezhniy protsess vazhen po otnosheniyu k poyavleniyu etikh organizmov. Tol'ko ponimanie immunogenetiki tuberkuleza mozhet uskorit' diagnostiku dannogo zabolevaniya, a takzhe yavit'sya puskovym momentom v razrabotke novykh protivotuberkuleznykh preparatov.