Description
LAP Lambert Academic Publishing Izuchenie Vzaimodeystviya Ligandov S Adenozinovymi Retseptorami in Silico 2012 Edition by Ivlev Il'ya
Adenozinovyy retseptor podtipa A2b ekspressiruetsya mnogimi immunnymi kletkami i oposreduet razvitie i podderzhanie khronicheskogo vospaleniya pri bronkhial'noy astme. V svyazi s etim adenozinovyy retseptor podtipa A2b rassmatrivaetsya kak mishen' dlya terapii bronkhial'noy astmy, khronicheskoy obstruktivnoy bolezni legkikh. V kachestve instrumenta issledovaniya molekulyarnykh mekhanizmov ligand- retseptornykh vzaimodeystviy primenyalos' komp'yuternoe modelirovanie. Byli sozdany komp'yuternye modeli adenozinovogo retseptora podtipa A2b i dvukh ego mutantnykh form (MODELLER), a takzhe 14 aktivatorov i 10 ingibitorov dannogo retseptora (ChemSketch). Na osnovanii poluchennykh modeley byl proizveden komp'yuternyy raschet ligand-retseptornykh vzaimodeystviy v programme AutoDock 4.0. Ustanovlena predraspolozhennost' vzaimodeystviya aktivatorov i ingibitorov s opredelennymi aminokislotami ligand-svyazyvayushchego tsentra adenozinovogo retseptora podtipa A2b.